The effects of the combination of ketamine and medetomidine intravenous (IV) anaesthesia on haematological parameters were evaluated in six sahel goats comprising of 5 females and 1 male with mean body weight of 19 ± 1.4kg. Each goat was given a recommended dose of the drugs combination: medetomidine at 0.01mg/kg and ketamine at 5mg/kg body weight IV. Pre injection blood samples were obtained a...

Background: OCR commonly occurs during strabismus surgery, producing bradycardia, arrhythmias and even cardiac arrest after manipulation of orbital structures. Ketamine is NMDA receptor antagonist acts as an analgesic. Aim: To determine the effect ketamine premedication on prevention surgery. Study design: Randomized control trial Methodology: 60 patients were randomly divided into two groups i...

BACKGROUND Drug interactions may reveal mechanisms of drug action: additive interactions suggest a common site of action, and synergistic interactions suggest different sites of action. We applied this reasoning in a review of published data on anesthetic drug interactions for the end-points of hypnosis and immobility. METHODS We searched Medline for all manuscripts listing propofol, etomidat...

This prospective study was conducted to determine the sedative effects of IV ketamine and fentanyl on vital signs and behavior. Twenty-seven children, classified as ASA I, with a mean age of 34 months, were studied. The dosages of IV ketamine and fentanyl given were 0.5 mg/kg and 0.5 mcg/kg, respectively, approximately every 15-20 min. The pulse rate averaged 125 throughout the case. Blood pres...

OBJECTIVE To compare a combined dose of ketamine and midazolam versus ketamine alone in the sedation of children requiring lumbar puncture. STUDY DESIGN A randomized, controlled study, conducted between January 2004 and December 2006. SETTING The Pediatric Emergency Department (PED) at Ankara Training and Research Hospital, Turkey. PARTICIPANTS A random sample of 99 children (59 boys, 40 ...

Accumulating evidence suggests that N-methyl-d-aspartate receptor (NMDAR) antagonists (e.g. ketamine) may exert rapid antidepressant effects in MDD patients. In the present study, we evaluated the rapid antidepressant effects of ketamine compared with the electroconvulsive therapy (ECT) in hospitalized patients with MDD. In this blind, randomized study, 18 patients with DSM-IV MDD were divided ...

UNLABELLED The combination of propofol and ketamine has been used for total IV anesthesia. This study was designed to clarify the effects of propofol-ketamine anesthesia on cerebral circulation by using transcranial Doppler ultrasonography. In Study 1, we examined the time course of time-mean middle cerebral artery blood flow velocity (Vmca) after ketamine (n = 10) or saline (n = 6) administrat...

UNLABELLED Ketamine, a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, has psychotomimetic activity. NMDA receptor antagonists cause morphological damage in the posterior cingulate cortex, which may be the brain region responsible for their psychotomimetic effects. Benzodiazepines are effective in preventing these effects through gamma-aminobutyric acid A (GABA(A)) receptor acti...

OBJECTIVE To evaluate the effects of an IV, low-dose ketamine-diazepam combination used for short-duration chemical restraint on the results of clinicopathologic testing in cats and to assess its practicality and tolerance. DESIGN Prospective case series. ANIMALS 42 client-owned cats of various breeds, ages, and health status. PROCEDURES Blood samples were obtained just prior to and just ...