Entandrophragma angolense is a medicinal plant used in folk medicine against several diseases including peptic ulcer. Methyl angolensate was isolated from E. angolense by recrystallization from methanol. The needle-like crystals were characterized and tested on isolated rabbit jejunum, guinea pig ileum and the rat fundus strip. The compound was also evaluated on the gastrointestinal transit in ...

Some pharmacodynamic effects of cefepime, a new injectable semisynthetic cephalosporin, were studied in laboratory animals and the following results were obtained. Cefepime maximally stimulated isolated guinea pig's ileum, rat's colon (80 μg/mL bath), and rabbit's duodenum (400 μg/mL bath). Contrarily, complete relaxation of isolated rat's fundic strip was produced by 80 μg/mL bath. Effects of ...

Plasma levels of serotonin are elevated in primary pulmonary hypertension even after bilateral lung transplantation, suggesting a possible etiologic role. Serotonin is released primarily from the small intestine. Anorectic agents, such as dexfenfluramine, which can cause pulmonary hypertension, are known to inhibit potassium channels in vascular smooth muscle cells. We examined the hypothesis t...

Two turmeric food powders (C1 and C2) were studied for curcuminoid content their effects on the guinea pig intestinal tract in vitro. C1 contained a higher than C2 (5.22% vs 2.31%). increased gallbladder (∼10%) biliary smooth muscle tone (∼15%), without affecting sphincter of Oddi contractility. was more effective lowering ileum (–22% −37%), whereas reverse occurred colon (-50% −20%). Standard ...

The objective of the study was to evaluate the use of goat ileum preparation for the estimation of unknown concentration of acetylcholine by three point bioassay. The graded doses of acetylcholine have shown dose dependent increase in contraction of isolated goat ileum. The responses obtained by this tissue preparation were similar to those with guinea pig ileum preparation. The goat ileum can ...

Effect of mitragynine, an indole alkaloid isolated from Thai medicinal plant kratom (Mitrugym speciosu), on electrically stimulated contraction was studied in the guinea-pig ileum. Mitragynine (1 nM 3 PM) inhibited the ileum contraction elicited by electrical stimulation, and its pD2 value was 6.91 + 0.04 (n = 5). Morphine (1 nM 1 PM) also inhibited the electrically stimulated contraction in a ...