نتایج جستجو برای: iscoms

تعداد نتایج: 95  

2005
Joel de León Luis E Fernández

In the Center for Molecular Immunology, a new adjuvant was designed and described. It was created to be used in vaccines for the treatment of immuno-compromised patients. Those very small sized proteoliposomes, called VSSP, combine in their structure the GM3 ganglioside, whith immune system suppressing properties and outer membrane vesicles of Neisseria meningitides with demonstrated immunostim...

Journal: :The Indian journal of medical research 2004
J McArthur K Schulze J Chin B J Currie K S Sriprakash S R Talay G S Chhatwal C A Guzmán M J Walker

BACKGROUND & OBJECTIVES The fibronectin binding protein Sfb1 of Streptococcus pyogenes is a well characterised antigen which induces protection against lethal challenge with group A streptococcus (GAS) when adjuvanted with cholera toxin B-subunit (CTB). As an alternative to CTB adjuvanted intranasal immunisations we investigated the immune responses generated in mice using Sfb1 incorporated in ...

Journal: :Journal of virology 1999
F R Brennan T Bellaby S M Helliwell T D Jones S Kamstrup K Dalsgaard J I Flock W D Hamilton

The humoral immune responses to the D2 peptide of fibronectin-binding protein B (FnBP) of Staphylococcus aureus, expressed on the plant virus cowpea mosaic virus (CPMV), were evaluated after mucosal delivery to mice. Intranasal immunization of these chimeric virus particles (CVPs), either alone or in the presence of ISCOM matrix, primed CPMV-specific T cells and generated high titers of CPMV- a...

Journal: :Veterinary research 2006
Eric Cox Frank Verdonck Daisy Vanrompay Bruno Goddeeris

In developing veterinary mucosal vaccines and vaccination strategies, mucosal adjuvants are one of the key players for inducing protective immune responses. Most of the mucosal adjuvants seem to exert their effect via binding to a receptor/or target cells and these properties were used to classify the mucosal adjuvants reviewed in the present paper: (1) ganglioside receptor-binding toxins (chol...

Journal: :Clinical and vaccine immunology : CVI 2014
Jenna Anderson Emmanuel Bréard Karin Lövgren Bengtsson Kjell-Olov Grönvik Stéphan Zientara Jean-Francois Valarcher Sara Hägglund

Bluetongue virus (BTV) causes bluetongue disease, a vector-borne disease of ruminants. The recent northerly spread of BTV serotype 8 in Europe resulted in outbreaks characterized by clinical signs in cattle, including unusual teratogenic effects. Vaccination has been shown to be crucial for controlling the spread of vector-borne diseases such as BTV. With the aim of developing a novel subunit v...

Journal: :Journal of immunology 2011
Peter Duewell Ulrich Kisser Klaus Heckelsmiller Sabine Hoves Patrizia Stoitzner Sandra Koernig Adriana B Morelli Björn E Clausen Marc Dauer Andreas Eigler David Anz Carole Bourquin Eugene Maraskovsky Stefan Endres Max Schnurr

Cancer vaccines aim to induce CTL responses against tumors. Challenges for vaccine design are targeting Ag to dendritic cells (DCs) in vivo, facilitating cross-presentation, and conditioning the microenvironment for Th1 type immune responses. In this study, we report that ISCOM vaccines, which consist of ISCOMATRIX adjuvant and protein Ag, meet these challenges. Subcutaneous injection of an ISC...

Journal: :Vaccine 1994
P de Vries J L Heeney J Boes M E Dings E G Hulskotte R Dubbes W Koornstra P ten Haaft L Akerblom S Eriksson

The immunogenicity and efficacy of an inactivated whole SIVmac (32H) preparation adjuvanted with muramyl dipeptide (SIV-MDP) and a gp120-enriched SIVmac (32H) ISCOM preparation (SIV-ISCOM), were compared by immunizing four rhesus macaques (Macaca mulatta) four times with SIV-MDP and four others in the same way with SIV-ISCOM. Two monkeys immunized with whole inactivated measles virus (MV) adjuv...

Journal: :Journal of immunology 2001
N K Polakos D Drane J Cox P Ng M J Selby D Chien D T O'Hagan M Houghton X Paliard

Current therapies for the treatment of hepatitis C virus (HCV) infection are only effective in a restricted number of patients. Cellular immune responses, particularly those mediated by CD8(+) CTLs, are thought to play a role in the control of infection and the response to antiviral therapies. Because the Core protein is the most conserved HCV protein among genotypes, we evaluated the ability o...

2013
Pamela Galvin Sarah Gildea Sean Arkins Cathal Walsh Ann Cullinane

BACKGROUND Antibodies against equine influenza virus (EIV) are traditionally quantified by haemagglutination inhibition (HI) or single radial haemolysis (SRH). OBJECTIVES To evaluate an ELISA for the detection of antibodies against influenza nucleoprotein in the diagnosis and surveillance of equine influenza (EI). METHODS The ELISA was compared with the SRH and HI tests. Serial serum sample...

2003
A. van Baalen Martien C. M. Poelen Petra de Vries Jolande Boes Vincenzo Cerundolo Albert D. M. E. Osterhaus Fons G. C. M. UytdeHaag

The routes used by antigen-presenting cells (APC) to convert the transmembrane fusion glycoprotein (F) of measles virus (MV) to HLA class I and class II presentable peptides have been examined, using cloned cytotoxic T lymphocytes in functional assays. Presentation by Epstein-Barr virus-transformed B lymphoblastoid cell lines was achieved using live virus, ultraviolet light-inactivated virus, a...

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