New highly sensitive voltammetric DNA-sensors have been developed for the detection of cytostatic drug doxorubicin based on Azure A electropolymerized various carbon nanomaterials, i.e., functionalized multi-walled nanotubes (fMWCNTs) and black (CB). Carbon materials promote electropolymerization dye applied as a matrix DNA molecules saturated with methylene blue (MB) molecules. Interaction int...

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A b s t r a c t . Oligonucleotides can be designed to bind to oligopurine.oligopyrimidine sequences of double-helical DNA. Binding occurs in the major groove and a triple helix is formed. Bifunctional oligonucleotide-intercalator conjugates have an increased affinity due to intercalation either at the triplex-duplex junction or within the triple-helical structure. Some intercalating agents can ...

A mononuclear complex of Zn(II), [Zn(DIP)(2) (DMP)] (NO(3))(2)·2H(2)O in which DIP is 4,7-diphenyl-1,10-phenanthroline and DMP is 4,4'-dimethyl-2,2'-bipyridine has been prepared and characterized by (1)HNMR spectroscopy, FT-IR, UV-Vis and elemental analysis techniques. DNA-binding properties of the complex were studied using UV-vis spectra, circular dichroism (CD) spectra, fluorescence, cyclic ...

The study of methylene blue (MB) binding to DNA has been carried out by fluorescence spectroscopy method. It was shown that on the fluorescence spectra of MB and its complexes with DNA two peaks exist at λ=583 nm and λ=682 nm wavelengths. Peak at λ=583 nm enhances with increasing of DNA concentration, but at λ=682 nm it decreases. The comparison of obtained data with the results received for DN...

The force-displacement response of a single duplex DNA molecule was measured. The force saturates at a plateau around 70 piconewtons, which ends when the DNA has been stretched about 1.7 times its contour length. This behavior reveals a highly cooperative transition to a state here termed S-DNA. Addition of an intercalator suppresses this transition. Molecular modeling of the process also yield...

Polycystic kidney disease (PKD) is a genetic disorder characterized by aberrant renal epithelial cell proliferation and formation progressive growth of numerous fluid-filled cysts within the kidneys. Previously, we showed that there elevated Notch signaling compared to normal cells contributes cystic cells. Quinomycin A, bis-intercalator peptide, has previously been shown target pathway inhibit...