نتایج جستجو برای: inos protein

تعداد نتایج: 1236459  

Journal: :Hypertension 1999
M C LaPointe E Isenović

The genes encoding inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2, also known as prostaglandin-endoperoxide synthase-2) are induced in many types of cells in response to proinflammatory cytokines. We have previously shown that interleukin-1beta (IL) stimulates iNOS and COX-2 mRNA in cardiac myocytes. Because IL has been shown to activate mitogen-activated protein kinase (MAP...

1999
Margot C. LaPointe Esma Isenović

The genes encoding inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2, also known as prostaglandin-endoperoxide synthase-2) are induced in many types of cells in response to proinflammatory cytokines. We have previously shown that interleukin-1b (IL) stimulates iNOS and COX-2 mRNA in cardiac myocytes. Because IL has been shown to activate mitogen-activated protein kinase (MAPK) ...

Journal: :American journal of physiology. Lung cellular and molecular physiology 2013
Émilie Boncoeur Guillaume F Bouvet Francis Migneault Valérie Tardif Pasquale Ferraro Danuta Radzioch Juan B de Sanctis David Eidelman Karuthapillai Govindaraju André Dagenais Yves Berthiaume

Nitric oxide (NO) plays an important role in innate host defense and inflammation. In response to infection, NO is generated by inducible nitric oxide synthase (iNOS), a gene product whose expression is highly modulated by different stimuli, including lipopolysaccharide (LPS) from gram-negative bacteria. We reported recently that LPS from Pseudomonas aeruginosa altered Na⁺ transport in alveolar...

1997
YU-LI LIN

Nitric oxide (NO) plays an important role in inflammation and multiple stages of carcinogenesis. We investigated the effect of various tea polyphenols and caffeine on the induction of NO synthase (NOS) in thioglycollate-elicited and lipopolysaccharide (LPS)-activated peritoneal macrophages. Gallic acid (GA), (2)-epigallocatechin (EGC), and (2)-epigallocatechin-3-gallate (EGCG), the major tea ca...

Journal: :Carcinogenesis 1996
F M Robertson B W Long K L Tober M S Ross T M Oberyszyn

The present studies examined the temporal sequence of inducible nitric oxide synthase (iNOS) gene expression and the cellular sources of iNOS protein and of 3-nitrotyrosine, as a marker of production of nitric oxide-derived reactive nitrogen intermediates during murine multi-stage carcinogenesis. Levels of iNOS mRNA in dorsal skin isolated from acetone-treated female Sencar mice were 2.5-fold h...

Journal: :The Analyst 2009
Francesca Palombo Hao Shen Lea Esther S Benguigui Sergei G Kazarian Rita K Upmacis

Inducible nitric oxide synthase (iNOS) has previously been shown to contribute to atherosclerotic lesion formation and protein nitration. Micro attenuated total reflection (ATR)-Fourier transform infrared (FTIR) spectroscopic imaging was applied ex vivo to analyse lesions in atherosclerotic (ApoE-/-) mice. Histologies of cardiovascular tissue of ApoE-/- mice that contain the gene for iNOS and A...

Journal: :Investigative ophthalmology & visual science 1994
M Mandai N Yoshimura M Yoshida M Iwaki Y Honda

PURPOSE To evaluate the role of nitric oxide synthase (NOS) in endotoxin-induced uveitis (EIU). METHODS EIU was caused in Lewis rats by injecting lipopolysaccharide (LPS) into the foot pad, and the effects of an NOS inhibitor, NG-nitro L-arginine (NA), was comparatively studied by the simultaneous administration of NA and LPS. Total NOS and inducible NOS (iNOS) activities were differentially ...

Journal: :Circulation 2001
S M Wildhirt M Weis C Schulze N Conrad S Pehlivanli G Rieder G Enders W von Scheidt B Reichart

BACKGROUND Inducible nitric oxide synthase (iNOS) is expressed and is functionally active in the presence of transplant arteriosclerosis. However, the early involvement of iNOS in alterations of microvascular endothelial function in the absence of preexisting lesions remains unclear; this information would be of prognostic value. We studied the course of iNOS mRNA expression, transcardiac nitri...

Journal: :Molecular pharmacology 2002
Malin Söderberg Françoise Raffalli-Mathieu Matti A Lang

Interaction of two members of the heterogeneous nuclear ribonucleoprotein (hnRNP) family with the 3'untranslated region (UTR) of the murine inducible nitric-oxide synthase (iNOS) mRNA is demonstrated in this study. An iNOS RNA-protein complex is formed using protein extracts from untreated and septic shock treated mouse liver. UV cross-linking reveals that the complex consists of at least two p...

Journal: :American journal of physiology. Renal physiology 2001
D Pérez-Sala E Cernuda-Morollón M Díaz-Cazorla F Rodríguez-Pascual S Lamas

Nitric oxide (NO) and cGMP may exert positive or negative effects on inducible NO synthase (iNOS) expression. We have explored the influence of the NO/cGMP pathway on iNOS levels in human mesangial cells. Inhibition of NOS activity during an 8-h stimulation with IL-1beta plus tumor necrosis factor (TNF)-alpha reduced iNOS levels, while NO donors amplified iNOS induction threefold. However, time...

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