We report a rare case of a 38-year-old female who presented with sudden onset flaccid quadriplegia and respiratory arrest with no significant past clinical history. She was later found to have hypokalemia due to distal renal tubular acidosis and further diagnosed as case of Sjogrens Syndrome.

BACKGROUND Primary periodic paralyses are rare inherited muscle diseases characterised by episodes of flaccid weakness affecting one or more limbs, lasting several hours to several days, caused by mutations in skeletal muscle channel genes. OBJECTIVES The objective of this review was to systematically review treatment of periodic paralyses. SEARCH STRATEGY We searched the Cochrane Neuromusc...

A neural network model that exhibits stochastic population bursting is studied by simulation. First return maps of interburst intervals exhibit recurrent unstable-periodic-orbit(UPO)-like trajectories similar to those found in experiments on hippocampal slices. Applications of various control methods and surrogate analysis for UPO detection also yield results similar to those of experiments. Ou...

Heterologous expression of sodium channel mutations in hypokalemic periodic paralysis reveals 2 variants on channel dysfunction. Charge-reducing mutations of voltage sensing S4 arginine residues alter channel gating as typically studied with expression in mammalian cells. These mutations also produce leak currents through the voltage sensor module, as typically studied with expression in Xenopu...

Among the human diseases caused by ion channel mutations hypokalemic periodic paralysis (HypoPP) has thrown up more than its fair share of puzzles. Patients have attacks of skeletal muscle paralysis associated with low serum potassium, and harbor dominant mutations affecting the muscle calcium (CaV1.1) or sodium (NaV1.4) channels respectively. Why do mutations in either channel converge on a co...

Hypokalemic paralysis periodic (HypoKPP) also known as familial hypokalemic (FHPP) or primary FHPP is rare case characterized by muscle weakness and estimated prevalence of around 1 in 100.000. Insulin a treatment for diabetes that decreases blood potassium levels, therefore, it necessary to further investigate the causes hypokalemia. This will be topic discussion if there correlation with FHPP...

'INSERM U 134 and Fed6ration de Neurologie, H6pital de la Salpetriere, 'INSERM U 155, 1D6partement de P6diatrie and 4Dipartement de N6phrologie, H6pital Necker, and 'INSERM U 153, Paris; 'Abteilung flir Angewandte Physiologie, Universita Ulm, Ulm; 7Servi~o Neurologia, Hospital de Egaz Moniz, Lisbon; 'Neurology and Human Genetics Departments, Leiden University, Leiden; 9H6pitaux de Lyon, Lyon; '...