Background: Plastic and polymeric materials remain in the soil given the fact that they are derived from petroleum resources. However, such pollution has created a special challenge for human societies. The use of biodegradable packaging has received more attention. The general purpose of this study was to investigate the use of a mixture film of whey protein concentrate and reinforced hydroxy...

The morphological evolution of graft copolymer-based nano-objects was monitored by light scattering and electron microscopy during their formulation in water polymerization induced self-assembly using a photo-mediated reversible addition–fragmentation chain transfer mechanism. copolymer models used were composed dextran backbone bearing poly(2-hydroxypropyl methacrylate) grafts two degrees (X)....

Hydroxypropyl methylcellulose (HPMC) is a polymer made of cellulose backbone with etherified methoxy and hydroxypropyl substitutions that undergoes reversible inverse thermo-gelation upon heating. The follows two-step mechanism: first, phase separation occurs, then fibrils, formed in the polymer-rich phase, entangle to form three-dimensional gel network. This work aims at understanding influenc...

The efficient syntheses of 5-(2-hydroxyethyl)- and 5-(3-hydroxypropyl)-substituted pyrimidine derivatives bearing 2,3-dihydroxypropyl, acyclovir-, ganciclovir- and penciclovir-like side chains are reported. A synthetic approach that included the alkylation of an N-anionic-5-substituted pyrimidine intermediate (method A) provided the target acyclonucleosides in significantly higher overall yield...

The mutagenic activity of N-nitrosobis(2-oxopropyl)amine (BOP), N-nitroso(2-hydroxypropyl) (2-oxopropyl)amine (HPOP), N-nitrosobis(2-hydroxypropyl)amine (BHP), N-nitrosomethyl-2-oxopropylamine (MOP), and N-nitrosomethyl-2-hydroxypropylamine (MHP) was examined in the Ames liquid incubation assay, using hamster liver homogenate for metabolic activation, and in the hamster liver cell-mediated V79 ...

A six-month repeated-dose dermal toxicity study fo11owed by a 30-day recovery test of hydrophobically modified hydroxypropyl methylcellulose (HM-HPMC), a new ceLlulose derivative used as a thickener for topical pharmaceuticals, was conducted using rats, Aqueous paste of HM-HPMC was applied to the skin ofrats once daily at dose levels up to 60 mg/kglday, which was the highest dose that could be ...

Advantages of the supercritical fluid (SCF) process compared to the conventional solution stirring method (CSSM) in the preparation of daidzein-hydroxypropyl-β-cyclodextrin (HPβCD) complexes were investigated. Formation of daidzein/ HPβCD inclusion complexes was confirmed by Fourier transformed-infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), X-ray diffraction (XRD) and sc...

A new type of chitosan/2-hydroxypropyl-β-cyclodextrin composite membrane have been developed for the encapsulation and controlled release of gallic acid. The morphology of the composite membrane was investigated by infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM), whereas swelling gallic acid and release properties were investigated by UV-visible spectroscopy. The release be...

A series of (R)-N-Cbz-2-alkyl-2-amino-3-hydroxypropyl acetates was prepared by enzymatic acetylation of NCbz-2-alkyl-2-aminopropane-1,3-diols with immobilized lipoprotein lipase from Pseudomonas sp. in up to 98% enantiomeric excess (ee). Enantiodivergent oxidation of (R)-N-Cbz-2-alkyl-2-amino-3-hydroxypropyl acetates readily furnished (R)and (S)-substituted serines ( -benzylserines and -methyls...