نتایج جستجو برای: hydroxamic acids
تعداد نتایج: 265477 فیلتر نتایج به سال:
magnesium is extracted with a chloroform solution of n-p-tolyl-2- thenohydroxamic acid (pttha) from aqueous solution of ph 9.5 .mg-pttha complex is colourless and the colour is developed by adding quinalizarin into the extract. lmax and e of the complex are 590nm and 2.8´103 lmol -1cm-1respectively.most common ions do not interfere in the determination of magnesium. the spectral characteristic...
Peroxidative oxidations of chemical carcinogens including N-substituted aryl compounds could result in their metabolic activation because the products react with cellular molecules and lead to cytotoxicity, mutagenicity, and carcinogenicity. In vivo, peroxidative activities are chiefly of neutrophilic leukocyte origin. Neutrophils may be attracted to the site(s) of exposure to carcinogen and, v...
Histone deacetylase (HDAC) inhibitors arrest cancer cell growth and cause apoptosis with low toxicity thereby constituting a promising treatment for cancer. In this study, we investigated the anti-tumor activity in lung cancer cells of the novel cyclic amide-bearing hydroxamic acid based HDAC inhibitors SL142 and SL325. In A549 and H441 lung cancer cells both SL142 and SL325 induced more cell g...
The scope, reactivity, and selectivity of the chiral hydroxamic acid-catalyzed kinetic resolution of chiral amines are improved by a new catalyst structure and a more environmentally friendly reaction protocol. In addition to increasing selectivity across all substrates, these conditions make possible the resolution of N-heterocycles containing lactams or other basic functional groups that can ...
Titanium raw materials are widely used for the synthesis of various functional – sorbents radionuclides and rare earth elements, additives, filler pigments, etc. Since most titanium concentrates imported, in line with import substitution program, production titanite concentrate from apatite-nepheline ores Khibiny deposits is a promising trend supplying national industry materials. The article p...
Continuing our interest in designing compounds preferentially potent and selective for MMP-13, we report on a series of hydroxamic acids with a flexible amide P1' substituents. We identify an amide which spares both MMP-1 and -14, and shows >500 fold selectivity for MMP-13 versus MMP-2 and -8.
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