Over the decades with outcome of industrial compliance, manufacturing process, formulation and development, Hot Melt Extrusion (HME) has also expanded acceptance. As a result adaptability, it developed itself in wide range as part pharmaceutical research development. New drug entities face failures or delays during including poor biopharmaceutical properties, toxicities lack efficacy. To overco...

The PCR technique often yields nonspecific products. To overcome this problem, a simple, specific and efficient method was designed: touch-up and loop incorporated primers (TULIPS)-PCR. This approach utilizes loop primers (i.e., additional nontemplate 5' sequence that self-anneals to the 3' region and inhibits initiation of polymerization). Upon heating of the reaction, the primers melt, initia...

Curcumin is coming from the Curcuma longa which gives golden color and have the biological importance. As per the survey it is water insoluble, the poor solubility and wettability of curcumin leads to poor dissolution and hence shows poor bioavailability. The present study is aimed at increasing solubility of drug using solid dispersion technique. The solid binary systems were prepared using di...

We use hydrodynamic modelling combined with known data on mantle melting behaviour to examine the potential for decompression melting of lithosphere beneath a large terrestrial impact crater. This mechanism may generate sufficient quantity of melt to auto-obliterate the crater. Melting would initiate almost instantaneously, but the effects of such massive mantle melting may trigger long-lived m...

The present study investigates the effect of crystalline and amorphous carriers for the improvement of dissolution profile of broad spectrum antifungal agent Itraconazole. A comparative study was performed to estimate the ability of Poloxamer-407 (crystalline carrier) and modified Gum Karaya (amorphous carries) for enhancing the dissolution profile of Itraconazole (BCS class II). Solid dispersi...

Hot die forging is a forming method widely used in the automobile industry, shipbuilding, and aerospace industry. In hot process of aluminum alloy, “mold sticking” defect often occurs results low productivity short life. Herein, we prepared TiB2 reinforced nickel-based coatings by combined use plasma transferred arc melt injection method, investigated morphology properties composite conditions....