Introduction Ischemic postconditioning is a method that shows evidence of efficacy in minimizing reperfusion injury; however, its effectiveness in preventing injuries in distant organs is still unknown, especially in those who have undergone mesenteric ischemia and reperfusion. Objective To evaluate the effect of ischemic postconditioning in preventing reperfusion injury in the liver of rats ...

Computed tomography (CT) evaluation of the acute polytrauma patient has become well established as a mainstay of ER triage in hemodynamically stable patients. The radiologist plays a pivotal role in directing management by identifying and appropriately categorizing the severity of a patient's injuries. High-grade liver injuries have undergone an increasing trend of nonoperative management over ...

BACKGROUND Nonoperative management of blunt hepatic injuries is highly successful. Complications associated with high-grade injuries, however, have not been well characterized. The purpose of the present study was therefore to define hepatic-related complications and associated treatment modalities in patients undergoing nonoperative management of high-grade blunt hepatic injuries. METHODS Th...

BACKGROUND The use of methylprednisolone (MP) and other corticosteroids for the treatment of acute liver allograft rejection is associated with severe toxicities in nontarget tissues. Therefore, selective delivery of MP to the liver may improve its efficacy and alleviate its side effects. We investigated the effects of a novel liver-targeted dextran prodrug of MP (DMP) in an orthotopic rat live...

BACKGROUND Severe liver injury in trauma patients still accounts for significant morbidity and mortality. Operative techniques in liver trauma are some of the most challenging. They include the broad and complex area, from damage control to liver resection. MATERIAL AND METHOD This is a retrospective study of 121 trauma patients with hepatic trauma American Association for Surgery of Trauma (...

Background: Caustic substance ingestion is known for causing a wide array of gastrointestinal and systemic complications. In Russia, ingestion of acetic acid is a major problem which annually affects 11.2 per 100,000 individuals. The objective of this study was to report and analyze main complications and outcomes of patients with 70% concentrated acetic acid poisoning. Methods: This was a retr...

this prospective study, conducted in 8 cities of iran from 1999 to 2000. out of total 16,573 trauma patients, 106 (0.63%) included in this study had renal injury. this study aimed at investigation of incidence, etiology and management of renal trauma patients in iran. they were 87 (82.1%) male and 19 (17.9%) female patients. renal trauma mechanism was mainly blunt injury (93.4%). road traffic c...

OBJECTIVES To analyze strategies of operative management (OM) and non-operative management (NOM), mortality, and morbidity of hepatic trauma patients. METHODS We retrospectively reviewed 296 consecutive patients with hepatic trauma at the Department of Hepatobiliary Surgery, 101st Hospital of PLA, Wuxi, Jiangsu, China a single level one trauma center between January 2003 and December 2012. Da...

background:methotrexate (mtx) is one of the most commonly used disease-modifying antirheumatic drugs in the treatment of rheumatoid arthritis (ra) which can be associated with toxic effects on different organs. this study was designed to investigate the hepatotoxic effects in ra patients treated with mtx. methods: in this cross-sectional observational study, ra patients who received standard do...