Abbreviations: Ach, acetylcholine; Cch, carbachol; mAChR, CHO, chinese hamster ovary; COPD, chronic obstructive pulmonary disease; CRC, concentration-response curve; DMEM/F12, Dulbecco’s Modified Eagle Medium nutrient mixture F-12; DMSO, dimethylsulfoxide; DR, dose ratio; FLIPR, fluorometric imaging plate reader; hERG, human ether-a-go-go-related gene; KH, Krebs’ Henseleit; KRH, Krebs’ Ringers ...

The effects of different concentrations of the hydroalcoholic extract of dried powdered leaves of Cichorium intybus L., on CCl4-induced hepatotoxicity in vivo in rats and CCl4-induced cytotoxicity in isolated rat hepatocytes were investigated. Rats received different concentrations of the extract by i.p. injection for 3 consecutive days before the injection of (3ml/kg) CCl4 (i.p.). Twenty four ...

Introduction: It was shown in a previous study, that MCPIP, a cilostamide derivative, increased atrial contraction force without changing contraction rate. To improve this property, two new derivatives of cilostamide were synthesized and their effects on PDE3 activity and isolated rat atria contraction were investigated. Methods: The inhibitory effect of each compound on PDE3 enzyme was dete...

The effects of different concentrations of the hydroalcoholic extract of dried powdered leaves of Cichorium intybus L., on CCl4-induced hepatotoxicity in vivo in rats and CCl4-induced cytotoxicity in isolated rat hepatocytes were investigated. Rats received different concentrations of the extract by i.p. injection for 3 consecutive days before the injection of (3ml/kg) CCl4 (i.p.). Twenty four ...

Background: Corn silk (CS) is widely used in Iranian traditional medicine and Feijoa sellowiana(FS) is a native plant widespread in the Southern parts of Iran. The aim of the present study was to assess renal protective activities of CS and FS against dosage induced injury by ecstasy (MDMA) using insitu rat renal perfusion (IRRP) system.Methods: Hydro-alcoholic extract of CS and FS (10, 20, 40 ...

the voltammetric behaviour of sulfadoxine (sdn) was studied at a glassy carbon electrode in 0.2 m phosphate buffer solutions using cyclic, differential-pulse (dpv) and square wave voltammetry (swv). the dependence of the current on ph, concentration, and scan rate was investigated to optimize the experimental conditions for the determination of sdn. the oxidation process was shown to be diffusi...

This paper presents a new approach to global clock distribution in which traditional tree-driven grids are augmented with onchip inductors to resonate the clock capacitance at the fundamental frequency of the clock node. Rather than being dissipated as heat, the energy of the fundamental resonates between electric and magnetic forms. The clock drivers must only provide the energy necessary to o...

BACKGROUND Vascular endothelium is covered by a glycocalyx. Damage to the glycocalyx after systemic inflammation or ischaemia/reperfusion contributes to increased vascular permeability and leucocyte adhesion. The underlying mechanisms leading to ischaemia/reperfusion-induced glycocalyx shedding are incompletely understood, in terms of lack of oxygen, absence of flow, or return of oxygen. METH...

The impact of reduced hepatic flow on lactate uptake and gluconeogenesis was examined in isolated glucagon-stimulated perfused livers from 24-h-fasted rats. After surgical isolation, livers were perfused (single pass) for 30 min with Krebs-Henseleit (KH) bicarbonate buffer, fresh bovine erythrocytes (hematocrit approximately 20%), and no added substrate. After this "washout" period, steady-stat...