Abstract Under hemolytic conditions, toxic heme is scavenged by hemopexin. Recently, the heme-binding properties of hemopexin have been reassessed, which revealed a K D ~ 0.32 nM as well stoichiometry one to two molecules binding A 66mer hemopexin-derived peptide that spans over three motifs was used verify earlier suggested heme-recruiting mechanism. Herein, we employed spectroscopic and compu...

“Il Principe” (the Prince) is the nickname given to a spectacular Mid Upper Palaeolithic (Gravettian) burial discovered at Arene Candide, Italy in 1942. Arene Candide is a large cave located about 90 m above sea level on the slope of the Caprazoppa promontory, along the Ligurian coast near Finale Ligure (Savona, Italy). The cave is named after a dune of white siliceous sand of aeolian origin, b...

Introduction: Iron metabolism was found to be implicated in several cancers. Few epidemiologic studies; focusing on iron intake and lung cancer (LC), reported positive associations between heme iron and red meat. Based on estimates of iron contents in representative foods, we conducted the present study with the aim of analyzing dietary iron and its role on the incidence of LC in Uruguayan men,...

Endoperoxide antimalarials based on the ancient Chinese drug Qinghaosu (artemisinin) are currently our major hope in the fight against drug-resistant malaria. Rational drug design based on artemisinin and its analogues is slow as the mechanism of action of these antimalarials is not clear. Here we report that these drugs, at least in part, exert their effect by interfering with the plasmodial h...

The R2PI-TOF spectra of supersonically expanded rare gas/chiral arene heteroclusters have been rationalized in terms of the distortion of the pi-electron density reflecting the different dipole and quadrupole momenta induced in the rare gas atoms by interaction with the opposite pi-faces of the chiral arene itself.

Reduction of [U(Ts(Tol))(Cl)(μ-Cl)U(Ts(Tol))(THF)2] [2, Ts(Tol) = HC(SiMe2NAr')3; Ar' = 4-MeC6H4)] with KC8 in toluene afforded the new arene-bridged diuranium complex [{U(Ts(Tol))}2(μ-η(6):η(6)-C6H5Me)] (3); combined structural, spectroscopic, magnetic, and computational analyses unambiguously confirm that the uranium centres in 3 are in the +5 oxidation state and the toluene is a 10π-tetraanion.

Heme is a double-edged sword. On the one hand, it has pivotal role as prosthetic group of hemoproteins in many biological processes ranging from oxygen transport and storage to miRNA processing. other heme can transiently associate with proteins, thereby regulating biochemical pathways. During hemolysis, excess heme, which released into plasma, bind proteins regulate their activity function. Th...