The pyrazoloacridine (PZA) analogue NSC366140 (PD115934) entered clinical trial based on unique preclinical characteristics including solid tumor selectivity in vitro, marked antitumor activity in vivo against murine solid tumors, selectivity against noncycling cells, and activity against multidrug-resistant tumor cells. After identification of the pre-clinical efficacy and an acceptable toxici...

High-dose doxorubicin has shown considerable activity in both previously treated and previously untreated patients with lymphoma. Because of the toxicities of doxorubicin at high dose, we elected to study a new anthracycline at doses comparable to doxorubicin at high dose, to assess response and toxicity. Epirubicin was administered at doses of 120 mg/m2, 150 mg/m2, and 180 mg/m2 every 3 weeks ...

Abstract Carbamazepine (CBZ) is one of the oldest antiepileptic drugs (AEDs) that still used for treatment tonic-clonic seizures in children. Long-term use AEDs induces potential toxic effects may remain undetermined a long time. Earlier studies have revealed wide spectrum hematological toxicities associated with CBZ. This study was conducted to unveil carbamazepine as an monotherapy on and imm...

Immune checkpoint inhibitors (ICIs) have been discovered to be associated with autoimmune toxicities that may present as dermatologic, gastrointestinal, hepatic, pulmonary, endocrine, and rarely hematologic reactions. Recent studies also hematological adverse effects a result of ICI use which isolated neutropenia is the gravest rarest manifestation. Asymptomatic cannot ignored, close monitoring...

Background: Mercury in any form is poisonous and mercury toxicity most commonly affects the nervous, gastrointestinal (GI) and urinary systems. The aim of this study was to investigate the specific effect associated with mercury toxicity and to evaluate the effectiveness of iron and vitamin B6 supplement on mercury-induced toxicities in rats. Methods: This experiment was performed on 25 rats...

objective: pinus eldarica (p. eldarica) is one of the most common pines in iran which has various bioactive constituents and different uses in traditional medicine. since there is no documented evidence for p. eldarica safety, the acute and sub-acute oral toxicities of hydroalcoholic extract of p. eldarica bark were investigated in male and female wistar rats in this study. materials and method...

Background: Patient-reported outcomes (PROs) of quality of life (QOL) during chemotherapy involving lung cancer are very important for the medical staffs. Patients’ satisfaction and healthy changes were evaluated by the patient-self assessment. Materials and Methods: From July 2007 to April 2008, a total of 19 patients received chemotherapy. The QOL data were collected by using the QOL question...