BAG-1 is a multifunctional protein that interacts with a wide range of cellular targets. There is accumulating evidence that overexpression of BAG-1 may play an important role in breast cancer; however, the functional consequences of BAG-1 expression and its mechanism of action in breast cancer cells have not been studied in detail. Here we demonstrate that BAG-1 overexpression completely prote...

bananas are climacteric fruits and controlling ripening is effective in reducing loss. this experiment studied the effect of packaging (plastic bag, edible wax and plastic bag, plastic bag and 2 or 4 g/kg potassium permanganate) over 5 weeks of cold storage on the quality and characteristics of cavendish cultivar bananas. the samples were removed from storage at 8, 16, 24, 32 and 40 days and fr...

The bag radius of the nucleon can be determined by MIT bag model based on electric and magnetic form factors of the nucleon. Also we determined the masses and magnetic moment of the nucleon with MIT bag model, using bag radius and compared with other results, suggests a suitable compatibility. Keywords—MIT bag model, masses and magnetic moment of the nucleon, bag radius of the nucleon.

(1) MICHAEL LENNARD 1923-1986 In his Obituary to Michael Lennard printed in our August number Donald Ratcliffe referred to his love of art and literature. He was a brilliant parodist and we reprint below with kind permission two excerpts from a contribution he made as a student to the 'Black Bag'. The theme was 'hernia' and readers will recognise echoes of Browning's 'Home thoughts from abroad'...

Pediatric ophthalmologists increasingly recognize that the ideal site for intraocular lens (IOL) implantation is in the bag for aphakic eyes, but it is always very difficult via conventional technique. We conducted a prospective case series study to investigate the success rate and clinical outcomes of capsular bag reestablishment and in-the-bag IOL implantation via secondary capsulorhexis with...

The C-terminal BAG domain is thought to play a key role in BAG-1-induced survival and proliferation by mediating protein-protein interactions, for example, with heat shock proteins HSC70 and HSP70, and with RAF-1 kinase. Here, we have identified thioflavin S (NSC71948) as a potential small-molecule chemical inhibitor of these interactions. NSC71948 inhibited the interaction of BAG-1 and HSC70 i...