1. Gynecological Malignancies: Gynecological malignancies are common accounting for 10-15% of all female malignancies [Kehoe, 2006]. Gynecological cancers are usually treated by surgery, chemotherapy and/ or radiotherapy. The management of patients with malignant gynecological disease depends upon the grade and stage of the malignancy, as well as the organ of origin. In endometrial cancer, earl...

High pre-treatment plasma D-dimer levels have been reported as a factor associated with a poor prognosis in different types of malignancies, including pancreatic, gastric, colorectal, lung, and nasopharyngeal carcinoma. Here, we performed a meta-analysis to determine the association of plasma D-dimer levels and long term survival in gynecological cancers, including ovarian, cervical and endomet...

RAPGEF1 (also known as C3G and GRF2) is a guanine nucleotide exchange factor that releases GDP from the inactive Rap1 protein, facilitating its subsequent activation by the binding of GTP. Rap1 plays regulatory roles in proliferation, differentiation and apoptosis. Amplification and overexpression of RAPGEF1 have been found in small cell lung cancers, suggesting an oncogenic role. In contrast, ...

Aim: To determine the impact of COVID-19 pandemic on overall practice histopathological and cytological laboratory at University Hospital Centre Rijeka, diagnosis most common cancers. Methods: The numbers reports, newly diagnosed cancers breast, lung, colon, endometrium, prostate, molecular tests for EGFR mutations HPV were extracted. Two periods, from March 1 to September 30 in 2019 2020 analy...

The Wnt signaling pathway is evolutionary conserved and controls many biological processes like cell proliferation and differentiation. It also provides planar polarity, regulation of the cell cycle, and cell adhesion during both the embryonic and adult period. However, it has been widely considered in the literature that some pathological alterations in various biomolecules involved in this pa...

OBJECTIVE Carcinoma of the cervix is still the most common gynecological malignancy among women in the developing nations. The purpose of this study is to review the pattern of carcinoma of the cervix in Zaria, Northern Nigeria. METHOD This is a retrospective study of patients seen at the Gynecologic oncology unit of Ahmadu Bello University Teaching Hospital, Zaria, Nigeria between November 2...

INTRODUCTION Infertility is as an important and common problem in couples necessitating assisted reproductive technology (ART) or drug therapy. Infertility is known as a risk factor for ovarian, breast and endometrial cancer. We aimed on evaluation of the history of primary infertility and previous ART in patients with the above-mentioned cancers. MATERIAL AND METHOD In this retrospective stu...

The aim of this review article was to evaluate the relationship and the possible etiological mechanisms between endometriosis, leiomyoma (LM) and adenomyosis and gynecological cancers, such as ovarian and endometrial cancer and leiomyosarcoma (LMS). MEDLINE was searched for all articles written in the English literature from July 1966 to May 2013. Reports were collected systematically and all t...

Aim: To perform an update of liver resection as treatment of liver metastases of gynecological cancers, as well as an update on these metastases. Bibliographical Search: PubMed Search 1990-2011 in English language. Authors reviewed only relevant articles. Results: No more than 20 relevant articles have been published on this topic, including case reports. We performed a classical review of the ...