نتایج جستجو برای: growth enhancer

تعداد نتایج: 836026  

Journal: :The Biochemical journal 2000
R J Rogers S E Chesrown S Kuo J M Monnier H S Nick

Diverse pro-inflammatory mediators regulate transcription of the gene (MnSOD) encoding the mitochondrial anti-oxidant protein manganese-superoxide dismutase. Understanding the regulation of this gene is crucial to comprehending its role in cytoprotection. In transfected lung epithelial cells, a human-growth-hormone reporter gene system was utilized to identify a potential enhancer in the MnSOD ...

Journal: :Current Biology 2000
C. Kanduri C. Holmgren M. Pilartz G. Franklin M. Kanduri L. Liu V. Ginjala E. Ullerås R. Mattsson R. Ohlsson

BACKGROUND During mouse prenatal development, the neighbouring insulin-like growth factor II (Igf2) and H19 loci are expressed monoallelically from the paternal and maternal alleles, respectively. Identical spatiotemporal expression patterns and enhancer deletion experiments show that the Igf2 and H19 genes share a common set of enhancers. Deletion of a differentially methylated region in the 5...

Journal: :research in pharmaceutical sciences 0

the purpose of this work was to study the effect of various permeation enhancers on the permeation of salbutamol sulphate (ss) buccal patches through buccal mucosa in order to improve the bioavailability by avoiding the first pass metabolism in the liver and possibly in the gut wall and also achieve a better therapeutic effect. the influence of various permeation enhancers, such as dimethyl sul...

Journal: :iranian journal of pharmaceutical research 0
hamid reza moghimi shahid beheshti medical university farshad hoseini shirazi pharmaceutical sciences research centre, shahid beheshti university of medical sciences, tehran, iran school of pharmacy, shahid beheshti university of medical sciences, tehran, iran mostafa saffari school of pharmacy, shahid beheshti university of medical sciences, tehran, iran

gene therapy is in its development stage as a novel method for cancer treatment. liposomes look promising as gene delivery vectors; however, investigations have shown that these vesicles are not doing well in some cases. it was decided here to investigate the possibility of augmentation of liposomal gene delivery by chemical penetration enhancers.cationic liposome containing antisense oligonucl...

Journal: :iranian journal of basic medical sciences 0
soliman mohammadi-samani department of pharmaceutics, school of pharmacy, shiraz university of medical sciences, shiraz, iran center for nanotechnology in drug delivery, shiraz university of medical sciences, shiraz, iran gholamhossein yousefi department of pharmaceutics, school of pharmacy, shiraz university of medical sciences, shiraz, iran center for nanotechnology in drug delivery, shiraz university of medical sciences, shiraz, iran farhad mohammadi department of pharmaceutics, school of pharmacy, shiraz university of medical sciences, shiraz, iran fatemeh ahmadi department of pharmaceutics, school of pharmacy, shiraz university of medical sciences, shiraz, iran center for nanotechnology in drug delivery, shiraz university of medical sciences, shiraz, iran

objective(s):drug delivery through the skin can transfer therapeutic levels of drugs for pharmacological effects. analgesics such as nsaids have gastrointestinal side effects and topical dosage forms of these drugs are mainly preferred, especially for local pains. meloxicam is one of nsaids with no topical form in the market. in this research, we attempted to quantify the skin permeation of a m...

Journal: :Development 2011
Lidia Pérez Lara Barrio David Cano Ulla-Maj Fiuza Mariana Muzzopappa Marco Milán

Trithorax-group and Polycomb-group proteins interact with chromosomal elements, termed PRE/TREs, to ensure stable heritable maintenance of the transcriptional state of nearby genes. Regulatory elements that bind both groups of proteins are termed maintenance elements (MEs). Some of these MEs maintain the initial activated transcriptional state of a nearby reporter gene through several rounds of...

Journal: :Biochemical and Biophysical Research Communications 2021

Abstract The multifunctionality of genome is suggested at some loci in different species but not well understood. Here we identified a DES-K16 region an intron the Kctd16 gene as chromatin highly marked with epigenetic modifications both enhancers (H3K4me1 and H3K27ac) silencers (H3K27me3) mouse spermatocytes. In vitro reporter assay demonstrated that exhibited significant enhancer activity spe...

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