We aimed to investigate the clinical implication of plasma xanthine oxidase (XO) activity in patients with type 2 diabetes mellitus (DM). Materials and methods. 127 were examined for DM (72 female 55 male). Serum biochemical variables include aspartate aminotransferase (AST), alanine (ALT), fasting (FPG) postprandial (PPG) glucose, glycohemoglobin A1c (HbA1c), total cholesterol, triglyceride, h...

on determinations of hemoglobin A1c by an immunoassay method. Diabetes Care 1998;21:983–6. 6. Roberts WL, Chiasera JM, Ward-Cook KM. Glycohemoglobin results in samples with hemoglobin C or S trait: a comparison of four test systems. Clin Chem 1999;45:906–9. 7. Eckman JR. The Sickle Cell Foundation of Georgia, Inc. The Sickle Cell Information Center. http://www.emory.edu/PEDS/SICKLE/hemoglb.htm ...

Sir, HbA1c testing is mainly used for monitoring glycaemic control in patients with diabetes. However, the World Health Organization now recommends that HbA1c can be used as a diagnostic test for diabetes, provided that stringent quality assurance procedures are in place and assays are standardised to criteria aligned to the international reference values. Laboratories use many different method...

An electrospray ionization-mass spectrometric procedure has been developed for determining glycohemoglobin. Whole-blood samples from 78 diabetic and 50 nondiabetic subjects (glycation range 3-15%, as determined by electrospray mass spectrometry) were diluted 500-fold in an acidic denaturing solvent and introduced directly into a mass spectrometer. The resulting mass spectra were then processed ...