Changes in uterine sialic acid and glycogen were studied in rats during days 1-6 of pregnancy. There was a sharp decline in uterine glycogen following mating, and thereafter increased gradually to reach a peak level on day 4 (4 PM). Coinciding with the entry of blastocysts into the uterus [between day 4 (10 PM) and day 5 (10 AM)] uterine glycogen decreased to a low level which was maintained up...

fenfluramine, an anorexigenic agent, is widely used in the treatment of obesity. besides its anorectic effect, it may also have some effects on general metabolism with the consequence of weight loss. in this study, the effect of fenfluramine on the concentrations of some parameters related to carbohydrate metabolism was investigated. it was shown that the serum insulin level was reduced by 41 %...

Glycogen is a complex glucose polymer found in a variety of tissues, including brain, where it is localized primarily in astrocytes. The small quantity found in brain compared to e.g., liver has led to the understanding that brain glycogen is merely used during hypoglycemia or ischemia. In this review evidence is brought forward highlighting what has been an emerging understanding in brain ener...

Insulin action is decreased by high muscle glycogen concentrations in skeletal muscle. Patients with McArdle's disease have chronic high muscle glycogen levels and might therefore be at risk of developing insulin resistance. In this study, six patients with McArdle's disease and six matched control subjects were subjected to an oral glucose tolerance test and a euglycemic-hyperinsulinemic clamp...

OBJECTIVE An adverse intrauterine environment indicated by both low birth weight and monozygosity is associated with an age- or time-dependent reduction in glucose disposal and nonoxidative glucose metabolism in twins, suggesting impaired regulation of muscle glycogen synthesis. RESEARCH DESIGN AND METHODS We measured the activities of glycogen synthase (GS), GS kinase (GSK)3 alpha, GS phosph...

Retinal tissue is exceptional because it shows a high level of energy metabolism. Glycogen content represents the only energy reserve in retina, but its levels are limited. Therefore, elucidation of the mechanisms controlling glycogen content in retina will allow us to understand retina response under local energy demands that can occur under normal and pathological conditions. Thus, we studied...

The biochemical effect of S-1,3-butanediol on streptozotocin induced diabetic rats was studied. Rats were made diabetic by the intraperitoneal injection of 40 mg/kg body weight streptozotocin in sodium citrate buffer. A dosage of 25 mmol/kg body weight of S-1,3-butanediol was injected intraperitoneally for treatment. The streptozotocin induced diabetic rats showed a marked increase in blood glu...

Normal hepatic glycogen levels are in the range 300-400 pmol/g of tissue wet weight [ 11. Starvation for periods longer than 12 h severely depletes the hepatic glycogen store, as it is rapidly mobilized to provide glucose for extrahepatic tissue metabolism [ 11. Typical levels remaining after mild starvation of 24-48 h are reported as being less than 40 pmol/g of tissue wet weight for the rat a...

Medicinal plants have curative properties due to the presence of various complex chemical compositions, which are found as secondary plant metabolites in one or more parts of the plant. The aim of this study was to compute the antidiabetic activity of Holarrhena antidysenterica   seeds extract in streptozotocin-induced diabetic rats. The experimental protocol designed as animals were divided i...