background and purpose : there has been no report in which preoperative evaluation of adc for prediction of post therapeutic outcome was presented. the aim of our study was to retrospectively evaluation the use of the apparent diffusion coefficient (adc) for the prediction of malignancy and the outcome of malignant astrocytic tumors. methods: we reviewed mri of 26 male and 14 female patients wi...

The group of brain tumors with mature components encompasses several pathological entities including: the ganglioneuroma; the gangliocytoma; the ganglioglioma; the desmoplastic ganglioglioma; the neurocitoma and a group of glioneuronal hamartomatous tumorous lesions, such as meningoangiomatosis. The dysembryoplastic neuroepithelial tumor is characterized by the presence of multiple cortical nod...

AIM Evidence suggests an association between MMP-9 functional gene polymorphisms and several tumors. The aim of this study was to investigate the possible role of single-nucleotide polymorphisms (SNP) at MMP-9 R279Q A/G, P574R G/C and R668Q G/A and R668Q (rs17577) genotypes with glial tumors in Turkey. MATERIAL AND METHODS The present series consisted of tissue samples obtained from 100 cance...

Microtubule-associated protein 2 (MAP2), a protein linked to the neuronal cytoskeleton in the mature central nervous system (CNS), has recently been identified in glial precursors indicating a potential role during glial development. In the present study, we systematically analyzed the expression of MAP2 in a series of 237 human neuroepithelial tumors including paraffin-embedded specimens and t...

Papillary glioneuronal tumor (PGNT) is a low-grade biphasic that composed of glial fibrillary acidic protein (GFAP)-positive cells and synaptophysin-positive neurons. We report case PGNT occurring in the right occipital lobe 48-year-old woman who presented with acute headache left homonymous hemianopsia, latter which was difficult to distinguish from malignant brain tumors because peritumoral e...

A Brain tumor is a growth of cells in the brain or near it. tumors can happen tissue close by locations include nerves, pituitary gland, central nervous system , meninges and membranes that cover surface brain[1]. glioma forms spinal cord makes an appearance from glial stem progenitor cells. Glial are type cell generally present system. Gliomas predominantly occur and, rarely, cord. They grow a...

PURPOSE Among central nervous system malignancies, cytochrome P450 1B1 (CYP1B1) expression has only been characterized in medulloblastoma. An immunotherapeutic agent targeting this antigen was shown to safely stimulate a good immune response. To evaluate the viability of further research efforts targeting this antigen, we examined the expression of CYP1B1 in glial cell malignancies. EXPERIMEN...

The human TAX-1 gene encodes a Mr 135,000 glycoprotein that is transiently expressed on the surface of a subset of neurons during development and is involved in neurite outgrowth. The TAX-1 gene has been mapped to a region on chromosome 1 that has been implicated in microcephaly and the Van der Woude syndrome. Using restriction landmark genome scanning to search for amplified genes in gliomas, ...

Gangliocytomas and Gangliogliomas are well-differentiated, slowly growing neuroepithelial tumors, composed of neoplastic, mature ganglion cells alone or in combination with neoplastic glial cells, respectively. Surgical resection is the standard of care, radiation used for malignant features or unresectable tumors. The epidemiology, clinical, pathologic and genetic features of these rare primar...

Cytophotometric DNA determination was performed on 8 glioblastomas, 4 astrocytomas, 2 oligoden drogliomas, and 4 meningiomas. Tumor cells were separated from a paraffin section and stained for DNA using the acriflavine-Feulgen nuclear reaction. Nonspecific dye-binding was blocked by azocarmin G staining. All the specimens were postirradiated to eliminate primary fluorescence and to stabilize th...