Background: Oncolytic herpes simplex virus (oHSV)-based vectors lacking γ34.5 gene, are considered as ideal templates to construct efficient vectors for (targeted) cancer gene therapy. Herein, we reported the construction of three single/dually-flourescence labeled and γ34.5-deleted, recombinant HSV-1 vectors for rapid generation and easy selection/isolation of different HSV-Based v...

Clinical observations show that the current spinal fusion with internal fixation has a nonfusion rate of 5%-35%; however, methods to promote are limited. This study aimed investigate role SDF-1-induced directional chemotaxis BMSCs in bone marrow chimera intervertebral mouse model. were isolated from and identified by detecting CD44/CD34 positive cells. (GFP-BMSCs) labeled GFP for tracking vivo....