Diffuse large B-cell lymphoma (DLBCL) is divided into germinal center B-like (GCB) DLBCL and activated B-like (ABC) DLBCL. In recent years, whole genome sequencing (WGS), whole exome sequencing (WES), and transcriptome sequencing (RNA-seq) have been performed for samples from many patients with DLBCL. Here, I present a review of the results of next generation sequencing data for DLBCL. Somatic ...

PWM techniques are becoming popular in the present day applications due to the control of amplitude and frequency in the output voltage from VSI. There are two popular approaches for the implementation of PWM Algorithms. Carrier based and Space Vector Approach. Both the approaches give the same performance, but due to simplicity, mostly carrier based approach has been preferred. A large variety...

This paper presents a review of conventional and novel carrier-based PWM methods that are used for control of multilevel inverters. Among the discussed methods are Phase disposition (PD) PWM, Opposite Phase disposition (POD) PWM, Alternative Phase disposition (APOD) PWM, Phase Shifted PWM and Asymmetrical PWM. The paper shows the simulation results and comparison of these methods. Key-Words: Re...

The activated B-cell-like (ABC) and germinal centre B-cell-like (GCB) subtypes of diffuse large B-cell lymphoma (DLBCL) were defined by their apparent derivation from different stages of B-cell differentiation and their differential response to chemotherapy [1]. With current chemotherapy supplemented with Rituximab, the ABC DLBCL subtype remains less curable [2,3], necessitating new approaches ...

Serine-threonine kinase CK2 is highly expressed and pivotal for survival and proliferation in multiple myeloma, chronic lymphocytic leukemia and mantle cell lymphoma. Here, we investigated the expression of α catalytic and β regulatory CK2 subunits by immunohistochemistry in 57 follicular (FL), 18 Burkitt (BL), 52 diffuse large B-cell (DLBCL) non-Hodgkin lymphomas (NHL) and in normal reactive f...

AIM The present study was aimed to assess the fasting and postprandial gingival crevicular blood (GCB) glucose and finger stick blood glucose measurements using a glucometer. MATERIALS AND METHODS A total of 30 subjects with periodontitis and positive bleeding on probing were considered. Subjects were instructed to report to the department after overnight fasting. Gingival crevicular blood sa...

Background In newly diagnosed osteosarcoma (OS) patients, the time between surgery and resumption of chemotherapy is 2-7 weeks. Delays > 16 days are associated with increased risk of relapse and decreased overall survival. Identifying an effective therapy that can be used postoperatively may prevent relapse. We investigated whether aerosol gemcitabine (GCB) initiated after tumor resection inhib...

The psychology of conspiracy theory beliefs is not yet well understood, although research indicates that there are stable individual differences in conspiracist ideation - individuals' general tendency to engage with conspiracy theories. Researchers have created several short self-report measures of conspiracist ideation. These measures largely consist of items referring to an assortment of pro...

Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoma, with an estimated 27 650 cases diagnosed in 2016. Gene expression profiling has identified three subtypes of DLBCL; germinal center B-Cell like (GCB), activated B-cell like (ABC) and primary mediastinal B-cell lymphoma (PMBL). This molecular heterogeneity is indicative of a unique cell of origin (COO) giving rise to each subtype...

The present studies have examined the effects of mitogens on induction of early response gene expression in normal peripheral blood T and Jurkat cells. Pokeweed mitogen (PWM) or anti-CD3 significantly increases c-jun messenger RNA (mRNA) levels in T cells. This transient PWM-related increase in c-jun transcripts is maximal after 15 to 30 minutes of exposure of T cells to PWM. PWM induces c-jun ...