introduction: in female rats sensitivity to antinociceptive treatment varies during estrous cycle stages. the role of gaba through gabab receptor in nociception has been established. the aim of the present study is to investigate the effect of intercerebroventicular injection of gabab receptor agonist (baclofen) and gabab antagonist (cgp35348) on pain sensitivity during different stages of estr...

The proper development of highly organized structures in the central nervous system is a complex process during which key events - neurogenesis, migration, growth, differentiation, and synaptogenesis - have to take place in an appropriate manner to create functional neuronal networks. It is now well established that GABA, the main inhibitory neurotransmitter in the adult mammalian brain, plays ...

The main inhibitory neurotransmitter, GABA, acts on both ligand-gated and G protein-coupled receptors, the GABAA/C and GABAB receptors, respectively. The later play important roles in modulating many synapses, both at the pre- and post-synaptic levels, and are then still considered as interesting targets to treat a number of brain diseases, including addiction. For many years, several subtypes ...

γ-Aminobutyric acid (GABA), which is synthesized by glutamic acid decarboxylase from glutamic acid, is the main inhibitory neurotransmitter and plays a key role in modulating neuronal activity in mammalian central nervous system. Addit ional ly , GABA is considered to be a multifunctional molecule that has different situational functions in some nonneuronal tissues. GABA exerts its actions via ...

The effect of lead on GABAB binding was studied on membranes obtained from acute and chronically lead-treated rats. Acute lead treatment reduced both GABAB affinity (KD) by about 30% and density of receptor (Bmax) by about 15%. On the contrary chronic lead treatment increased receptor capacity by about 20% in spite of decreased receptor affinity by 25%. Both acute and chronic lead treatment shi...

In the olfactory pathway of Drosophila, a GABAB receptor mediated presynaptic gain control mechanism at the first synapse between olfactory sensory neurons (OSNs) and projection neurons has been suggested to play a critical role in setting the sensitivity and detection range of the sensory system. To approach the question if such a mechanism may be realized in the pheromone recognition system o...

The effect of partial hippocampal kindling, a model of temporal lobe seizure, on monosynaptic inhibition mediated by GABA was studied. Kindled rats were given 15 nonconvulsive hippocampal afterdischarges, and control rats were given low frequency or no stimulations. At 1-2 d after kindling, paired-pulse depression (PPD) of the IPSCs recorded in CA1 neurons in vitro was significantly smaller in ...

The GABAB-mediated modulation of spinal neurons in the lamprey is investigated in this study. Activation of GABAB receptors reduces calcium currents through both low- (LVA) and high-voltage activated (HVA) calcium channels, which subsequently results in the reduction of the calcium-dependent potassium (KCa) current. This in turn will reduce the peak amplitude of the afterhyperpolarization (AHP)...

The distribution and function of GABAB receptors in spider peripheral mechanosensilla Izabela Panek1,2, Shannon Meisner1 and Päivi H. Torkkeli1 Department of Physiology and Biophysics, Dalhousie University, Halifax, Nova Scotia, B3H 4H7, Canada; Department of Biophysics, Institute of General and Molecular Biology, N. Copernicus University, 87-100 Torun, Poland Abbreviated title: GABAB receptors...

The metabotropic GABAB receptors mediate slow synaptic inhibition and consist of heterodimers of GABAB1 and GABAB2 subunits. The only known molecular diversity of the GABAB receptors arises from the two GABAB1 isoforms, but its functional significance has been unclear. Two studies in this issue of Neuron now demonstrate that GABAB1a and GABAB1b show strategically distinct subcellular localizati...