Schizophrenia is characterized by cognitive, social, and emotional impairments and by psychotic symptoms. Neuroimaging studies have reported abnormalities within the prefrontal cortex and it has been hypothesized that schizophrenia results from poor or miswired anatomical/functional connections. We have compared the functional connectivity within the frontal cortex in control and schizophrenic ...

The frontal lobes control wide-ranging cognitive functions; however, functional subdivisions of human frontal cortex are only coarsely mapped. Here, functional magnetic resonance imaging reveals two distinct visual-biased attention regions in lateral frontal cortex, superior precentral sulcus (sPCS) and inferior precentral sulcus (iPCS), anatomically interdigitated with two auditory-biased atte...

Lavie and colleagues recently suggested that cognitive control functions that are mediated by frontal cortex provide goal-directed control of selective attention, serving to minimize interference by goal-irrelevant distractors. Here we provide new evidence for this claim from an attentional capture paradigm. An event-related fMRI experiment shows that the presence (vs. absence) of an irrelevant...

Prior neuroimaging studies have supported the idea that human insular cortex plays an important role in processing and representing internal bodily states, also termed “interoception.” According to recent theoretical studies, interoception includes several aspects such as attention accuracy. However, there is no consensus on laterality location of insula support each aspect interoception. Thus,...

The Frontal Assessment Battery is a set of six subtests that is used widely to assess frontal cortical executive dysfunction. Performance on the Frontal Assessment Battery has been shown to be sensitive to various neurodegenerative diseases, but it has never been shown to be sensitive to damage restricted to the frontal cortex. Thus, despite its wide use, it has never been validated on an appro...

The Frontal Assessment Battery is a set of six subtests that is used widely to assess frontal cortical executive dysfunction. Performance on the Frontal Assessment Battery has been shown to be sensitive to various neurodegenerative diseases, but it has never been shown to be sensitive to damage restricted to the frontal cortex. Thus, despite its wide use, it has never been validated on an appro...

BUTTER, C. M. Perseveration in extinction and in discrimination reversal tasks /bllowing selective frontal ablations in Macaca mulatta. PHYSIOL. BEHAV. 4 (2) 163--171, 1969.--In order to determine whether the perseverative syndrome exhibited by monkeys with frontal lobe lesions can be fractionated by partial frontal lesions, monkeys with dorsolateral frontal lesions, those with orbital frontal ...

Size has a profound effect on the structure of the brain. Many brain structures scale allometrically, that is, their relative size changes systematically as a function of brain size. Here we use independent contrasts analysis to examine the scaling of frontal cortex in 43 species of mammals including 25 primates and 15 carnivores. We find evidence for significant differences in scaling between ...

Category and letter fluency tasks have been used to demonstrate psychological and neurological dissociations between semantic and phonological aspects of word retrieval. Some previous neuroimaging and lesion studies have suggested that category fluency (semantic-based word retrieval) is mediated primarily by temporal cortex, while letter fluency (letter-based word retrieval) is mediated primari...

Category and letter fluency tasks have been used to demonstrate psychological and neurological dissociations between semantic and phonological aspects of word retrieval. Some previous neuroimaging and lesion studies have suggested that category fluency (semantic-based word retrieval) is mediated primarily by temporal cortex, while letter fluency (letter-based word retrieval) is mediated primari...