Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative condition with phenotypic and genetic heterogeneity. It characterized by the selective vulnerability progressive loss of neural population. Here, induced pluripotent stem cell (iPSC) line was generated from dermal fibroblasts individual carrying p.G376D mutation in TDP-43 protein. Fibroblasts were reprogrammed using non-integ...

background: numerous in vitro reports suggest that low level laser therapy (lllt) affects cellular processes by biostimulation, however most of them emphasize on using visible light lasers which have low penetration. the aim of this study was to determine the effect of infrared laser light (which is more useful in clinic because of its higher penetration) on secretion of fibroblast growth facto...

background and aims. the aim of this study was to compare the biocompatibility of calcium-enriched mixture ce-ment (cem), composite resin and nano-particled mineral trioxide aggregate (np-mta) using human gingival fibroblasts. materials and methods. a comparative in vitro cell culture study was carried out using 60 single-rooted teeth which were assigned to the following four groups: 1) untreat...

The healthy-looking non-lesional (NL) psoriatic skin already carries some alterations. These alterations include extracellular matrix defects such as the disruption of laminin networks, which may lead to impaired keratinocyte adhesion basal membrane. This process is associated with aberrant expression α5β1 integrin complex and extradomain-A-containing fibronectin (EDA+FN) around keratinocytes. ...

Hidradenitis Suppurativa is a chronic inflammatory disease, the pathogenesis of which incompletely understood. Fibroblasts and Mast cells are important mediators wound healing fibrosis, disturbed in HS tissue. We demonstrate aberration fibroblast mast cell populations whole tissue RNA seq analysed by CIBERSORTx in-silico deconvolution, validated Nanostring Gene Expression Immunohistochemistry. ...

Fibrosis leads to failure of the skin, lungs, and other organs in systemic sclerosis (SSc); accounts for substantial morbidity mortality; lacks effective therapy. Recent findings implicated TGFβ-activated kinase 1 (TAK1), triggered by TGF-β toll-like receptor signaling, SSc pathogenesis. The objectives were evaluate activation TAK1 signaling axis patients antifibrotic ability pharmacological bl...