نتایج جستجو برای: fab subgroups
تعداد نتایج: 48201 فیلتر نتایج به سال:
The human combinatorial antibody library Fab 1 (HuCAL-Fab 1) was generated by transferring the heavy and light chain variable regions from the previously constructed single-chain Fv library (Knappik, A., Ge, L., Honegger, A., Pack, P., Fischer, M., Wellnhofer, G., Hoess, A., Wölle, J., Plückthun, A., and Virnekäs, B. (2000) J. Mol. Biol. 296, 57-86), diversified in both complementarity-determin...
BACKGROUND Fab antibody fragments in E. coli are usually directed to the oxidizing periplasmic space for correct folding. From periplasm Fab fragments may further leak into extracellular medium. Information on the cultivation parameters affecting this leakage is scarce, and the unpredictable nature of Fab leakage is problematic regarding consistent product recovery. To elucidate the effects of ...
We measured the flexibility of Fab and Fc arms of immunoglobulin using gold nanoparticles (GNPs). Enzyme-linked immunosorbent assay was performed to measure the affinity of anti-5 nm GNP antiserum against various sizes of GNPs. The flexibility of Fc was also measured by electron microscopy. The restricted binding affinity indicated that only a very limited amount of freedom was allowed for the ...
in this paper, we introduce some properties of an intuitionistic normal fuzzy m-subgroup of m- group with m-homomorphism and isomorphism. we study he image, the pre-image and the inverse mapping of the intuitionistic normal fuzzy m-subgroups.
221 samples of leukemic patients were studied, using morphologic, cytochemical staining pattern and immunophenotyping criteria. Patients included 63 children and 158 adults. Out of the adult group, 110 cases had acute leukemia including 67% AML, 330'{' ALL. In this group, 24 cases of CML" 19 cases of CLL, 4 cases of HCL and one case of plasma cell leukemia were classified. Out of 63 cases of le...
This study introduces the application of calcium-derivatized hydroxyapatite for purification of Fab. Fab binds to native hydroxyapatite but fails to bind to the calcium derivatized form. IgG, Fc, and most other protein contaminants bind to the calcium form. This supports Fab purification by a simple flow-through method that achieves greater than 95% purity from papain digests and mammalian cell...
This paper presents a series of experiments that were conducted to investigate in the instationary behavior of a wafer fab after changes in product mix. The experiments were performed using a simulation model of the front end area of an existing semiconductor fab. We observe how short-term increases in wafer starts of a product influence the cycle time and WIP of this product and of the other p...
OBJECTIVE To show data on the performance of healthy subjects in the Frontal Assessment Battery (FAB), correlating with gender, age, education, and scores in the Mini-Mental State Examination (MMSE). METHODS Two hundred and seventy-five healthy individuals with mean age of 66.4 ± 10.6 years-old were evaluated. Mean total FAB scores were established according to the educational level. RESULT...
BACKGROUND Inhibition of GPVI has been proposed as a useful antithrombotic strategy; however, in vivo proof-of-concept animal studies targeting GPVI are lacking. We evaluated a novel anti-human GPVI monoclonal antibody OM4 Fab in rats. METHODS AND RESULTS OM4 Fab specifically inhibited collagen-induced aggregation of rat platelets in vitro with an IC50 of 20 to 30 microg/mL but not ADP and AA...
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