نتایج جستجو برای: external validation gc gc
تعداد نتایج: 393236 فیلتر نتایج به سال:
Microalbuminuria in humans with Type 1 diabetes (T1D) is associated with increased urinary excretion of megalin, as well as many megalin ligands, including vitamin-D-binding protein (VDBP). We examined the DBA/2J diabetic mouse, nephropathy prone model, to determine if megalin and VDBP excretion coincide with the development of diabetic nephropathy. Megalin, VDBP, and 25-hydroxy-vitamin D (25-O...
Prematurely born infants commonly suffer respiratory dysfunction due to the immature state of their lungs. As a result, clinicians often administer glucocorticoid (GC) therapy to accelerate lung maturation and reduce inflammation. Unfortunately, several studies have found GC therapy can also produce neuromotor/cognitive deficits and selectively stunt the cerebellum. However, despite its continu...
PURPOSE Clinicopathologic features and biochemical recurrence are sensitive, but not specific, predictors of metastatic disease and lethal prostate cancer. We hypothesize that a genomic expression signature detected in the primary tumor represents true biological potential of aggressive disease and provides improved prediction of early prostate cancer metastasis. METHODS A nested case-control...
Small RhoGTPases, such as Cdc42 and RhoA, are key players in integrating external cues and intracellular signaling pathways that regulate growth cone (GC) motility. Indeed, Cdc42 is involved in actin polymerization and filopodia formation, whereas RhoA induces GC collapse and neurite retraction through actomyosin contraction. In this study we employed Förster Resonance Energy Transfer (FRET) mi...
دشت آبادان زون ساختاری واقع در انتهای جنوب غربی زاگرس است. هدف از این مطالعه بررسی ژئوشیمیایی سازندهای سرگلو، گرو، گدوان و کژدمی به عنوان سنگ های منشأ احتمالی و تعیین مشارکت این سازندها در هیدروکربورزایی، مطالعه نفت های موجود در مخازن (سروک، گدوان، فهلیان) دشت آبادان و تعیین پارامترهای نوع ماده آلی، بلوغ، بررسی ارتباط ژنتیکی بین نفت ها و تطابق نفت ها با سازندهای مورد مطالعه می باشد. در این مطال...
in order to investigate the medicinal species from montain of shirkooh (up village), in yazd provience, iran on three species by scientific names were heracleum persicum desf. ex fisch., c.a.mey. & avé-lall.; ziziphora clinopodioides lam. and nepeta asterotricha rech.f. were collected on june, july and august 2011. then all samples essential oils were extracted by hydro-distillation method (cla...
A current bottleneck in GC-MS metabolomics is the processing of raw machine data into a final datamatrix that contains the quantities of identified metabolites in each sample. While there are many bioinformatics tools available to aid the initial steps of the process, their use requires both significant technical expertise and a subsequent manual validation of identifications and alignments if ...
Previously, in the Asian Cancer Research Group (ACRG) project, we defined four distinct molecular subtypes in gastric cancer (GC). Mesenchymal (microsatellite stable with epithelial-to-mesenchymal transition phenotype, MSS/EMT) tumors showed the worst prognosis among all the subtypes. To develop a gene signature for predicting mesenchymal subtype GC, we conducted gene expression profiling using...
Single-nucleotide polymorphisms (SNPs) in microRNAs (miRNAs) have been suggested to influence the occurrence and progression of cancer through altering the expression and biological function of miRNAs. The aim of this study was to investigate whether the potential functional SNPs in MIR196A2 promoter had effect on the susceptibility to gastric cancer (GC) in a Chinese population.We conducted a ...
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