Aims: To assess and compare the body mass index (BMI), serum leptin, and lipid peroxidation represented by serum malondialdehyde (MDA) levels in epileptic patients on valproate (VPA) and topiramate (TPM) monotherapy for at least 6 months taking in consideration dosage and duration of therapy, in comparison to healthy controls. Methods: A cross-sectional, case-series study design was adopted, fo...

Epilepsy is defined as a chronic neurological disorder which is associated with recurrent seizures of cerebral origin. Epilepsy is one of the most common neurologic disease affecting almost 45 million people worldwide. More than often epilepsy demonstrates bimodal age distribution consisting of infancy and old age. Till today, the scenario surrounding the management of epilepsy is complex. Phen...

Purpose of review. To present an overview of the recent findings in pathophysiology and management of epileptic seizures in patients with gliomas. Recent findings. Low-grade gliomas are the most epileptogenic brain tumors. Regarding pathophysiology, the role of peritumoral changes (hypoxia and acidosis, blood–brain barrier disruption, increase or decrease of neurotransmitters and receptors) are...

BACKGROUND AND OBJECTIVES Epilepsy is one of the most frequent chronic neurological diseases. Although anesthesia for epilepsy patients is more common in neurosurgery, this group of patients needs, just as the general population, anesthesia for different diagnostic and therapeutic procedures. This article aims to address the issues of greatest interest to the anesthesiologist in the perioperati...

Voltage-gated sodium channels (VGSCs) are key mediators of intrinsic neuronal and muscle excitability. Abnormal VGSC activity is central to the pathophysiology of epileptic seizures, and many of the most widely used antiepileptic drugs, including phenytoin, carbamazepine, and lamotrigine, are inhibitors of VGSC function. These antiepileptic drugs might also be efficacious in the treatment of ot...