background and objectives: apoptosis of eosinophils is of significant value in assessing the airway inflammation in patients with asthma. our purpose was to investigate the degree of expression of the bcl-2 protein in sputum eosinophils during acute asthma exacerbation and its relationship with exacerbation severity.    materials and methods: the study was carried out in mostafa khomeini hospit...

Background: Eosinophil count is influenced by variations in climate, culture, diet and life style. Moreover it fluctuates in a person with exercise and environmental stimuli, mainly seasonal allergen exposure. This study was conducted to know the effect of pollen peaks on eosinophil count in normal, non-allergic adult women. Material & Methods: This experimental study was carried out in Women M...

The eosinophil granulocyte is an inflammatory cell involved in allergic diseases such as asthma and rhinitis. Eosinophil cationic protein (ECP) is a basic and potentially cytotoxic granule protein that is released from the eosinophil upon activation. The aim was to study secretion of molecular variants of ECP from blood eosinophils with the hypothesis that the stored noncytotoxic ECP is altered...

Eosinophils are proinflammatory cells that are associated with both allergic diseases and parasitic infections. In parasitic infections the eosinophil appears to be protective, but in allergic conditions eosinophil products are damaging and contribute to the tissue pathology of the disease. A particular property of eosinophils is that they can, like macrophages, exist in different states of act...

INTRODUCTION "Eosinophilic asthma" refers to an asthma phenotype characterized by predominance of eosinophils in the bronchial airways and corticosteroid responsiveness. Recent clinical trials of eosinophil-blocking agents have utilized a blood eosinophil count of 300 or 400 eosinophils/mm(3) or higher to identify subjects with moderate to severe asthma. We observed multiple instances of counts...

CONTEXT Limited population-based study focused on relationship between eosinophil and type 2 diabetes (T2D). OBJECTIVES We aimed to evaluate the relationship between peripheral eosinophil percentage and glucose metabolism and insulin resistance in a large sample size of Chinese population aged 40 and older. DESIGN AND METHODS A cross-sectional study was performed among 9,111 Chinese adults ...

Eosinophilic endomyocardial disease represents a major evolutive risk in chronic eosinophilia-associated disorders. Eosinophil granule proteins appear to be involved in cardiac injury, but the mechanisms leading to eosinophil infiltration and degranulation are not clear. Interleukin-5 (IL-5) has been recently shown to be produced by eosinophils and might play a role in both chemoattraction and ...

BACKGROUND Blood eosinophil count is a marker of eosinophilic airway inflammation and disease severity in asthma. However, blood neutrophil count might also be associated with disease severity. We tested the hypothesis that high blood eosinophil and neutrophil counts are both associated with the risk of asthma exacerbations among individuals with asthma from the general population. METHODS Fr...