Specific problematic issues addressed , page 8 Vygotsky's theory of learning and development, page 9 Subsequent developments in the Cultural-Historical Theory as a foundation for instructional practices, page 13 Description of the innovation, page 17 The authors are responsible for the choice and presentation of the facts contained in this publication and for the opinions expressed therein, whi...

introduction: the major histocompatibility complex (mhc) is a group of cell surface proteins that are essential for recognizing foreign molecules in human and other mammals. the physiologic function of mhc molecules is the presentation of peptides to t cells. in this study, we evaluated the purification of a class ii mhc molecule (hla-dr) from a human burkitt′s lymphoma cell line; daudi. materi...

Dr Deniz Aslan is a Consultant Psychologist and Lecturer, based at Department of Psychology, Roehampton University, London, UK and Langford Clinic, East Sussex, UK. Robert Edelmann is a Professor of Forensic and Clinical Psychology, Dr Diane Bray is the Head of Department and Dr Marcia Worrell is a Principal Lecturer, all are based at Department of Psychology, Roehampton University, London, UK....

i Acknowledgements I would like to express sincere gratefulness to: My advisor, Dr. Catherine Kotz, who has supported and encouraged me throughout these years to complete this project. She has taught me a type of work-ethic that I never had before. Martha Grace who has helped me with many experimental procedures. I could not have done anything without her help. Dr. Charles Billington for his su...

Diabetic retinopathy (DR) is a leading cause of blindness in working age adults. The objective of this study is to investigate the effects of vascular endothelial growth factor receptor 1 (VEGFR1) blockade on the complications of DR. Experimental models of diabetes were induced with streptozotocin (STZ) treatment or Insulin2 gene mutation (Akita) in mice. Protein expression and localization wer...

The 2016 edition of the Basic Cardiovascular Sciences (BCVS) Scientific Sessions was held from July 18 to July 21 in beautiful (and hot!) Phoenix, Arizona. This year’s program was put together by Program Co-chairs Raj Kishore (Temple University), Jay Zhang (University of Alabama), and Maria Kontaridis (Beth Israel Deaconess Medical Center). The meeting attracted ≈600 attendees representing 23 c...

PURPOSE Diabetic retinopathy (DR) has been classically considered a microcirculatory disease of the retina. However, before any microcirculatory abnormalities can be detected in ophthalmoscopic examination, retinal neurodegeneration is already present. The aim of the study was to analyze proapoptotic and survival signaling in the neuroretinas of diabetic patients at early stages of DR. METHOD...