نتایج جستجو برای: double strand break
تعداد نتایج: 297026 فیلتر نتایج به سال:
Double-strand DNA breaks occur upon exposure of cells to ionizing radiation and certain chemical agents or indirectly through replication fork collapse at DNA damage sites. If left unrepaired, double-strand breaks can cause genome instability and cell death, and their repair can result in loss of heterozygosity. In response to DNA damage, proteins involved in double-strand break repair by homol...
Alkaline and neutral elution techniques were used to charac terize the production of singleand double-strand DMA breaks in human diploid fibroblasts by incorporated radionuclides. 125I was incorporated in DMA as [125l]iododeoxyuridine, 3H as [3H]thymidine, and 14C as [14C]thymidine. Under frozen conditions, 125Iwas 3 times as efficient as 3H per decay in inducing singlestrand breaks and 6 times...
Association of DNA Polymerase (pol ) with Ku and Ligase IV: Role for pol in End-Joining Double-Strand Break Repair Kiran N. Mahajan, Stephanie A. Nick McElhinny, Beverly S. Mitchell, and Dale A. Ramsden* Lineberger Comprehensive Cancer Center, Department of Biochemistry and Biophysics, Curriculum in Genetics and Molecular Biology, and Departments of Pharmacology and Medicine, University of Nort...
In spite of its essential role as the carrier of genetic information, DNA is not an inert structure. The genome is susceptible to potentially mutagenic threats of both endogenous and environmental origin. A dramatic threat to the covalent structure of DNA is posed by breaks in the phosphate backbone affecting one or both strands of the Watson–Crick double helix. Ionizing radiation and certain c...
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