Background: This work investigated the dosimetry limitations of the random and systematic uncertainties of sliding window (SW) intensity modulated radiation therapy (IMRT). Materials and Methods: A Varian 21EX linear accelerator, Pinnacle3 treatment planning system and radiographic film dosimetry was used. The limitations of the SW were studied using beam modulation ranging from 2 to 10...

Recently, the developers of Eclipse have recommended the use of ionization chambers for all profile scanning, including for the modeling of VMAT and stereotactic applications. The purpose of this study is to show the clinical impact caused by the choice of detector with respect to its ability to accurately measure dose in the penumbra and tail regions of a scanned profile. Using scan data acqui...

introduction radiotherapy planning systems require many percentage depth dose (pdd) and profile measurements and there are various dosimeters that can be used to obtain these scans. as dose perturbation is particularly troublesome in smaller photon fields, using a low-perturbation, unshielded electron field diode (efd) in these fields is of interest. the aim of this work was to investigate the ...

Introduction: The dosimetric characteristics of patch sources including 32P, 90Y, 188Re and 166Ho, which are employed for radionuclide skin therapy, have been evaluated in current study Materials and Methods: The patch sources understudy were modeled by MCNPX Monte Carlo code and corresponding depth dose distribution, transverse dose profile and isodose curves...

introduction:  skin  sparing  is  one  of  the  most  desirable  characteristics  of  high  energy  photon  beams. however, the photons emerging from the target of linacs are contaminated by secondary  electrons  as  a  result  of  their  interactions  with  air,  collimators,  flattening  filter  and  any  other  objects in their path. this phenomenon tends to increase the skin dose received b...

introduction: the aim of present study was to estimate effective dose from most common procedures performed in nuclear medicine departments of golestan province. methods: data of nuclear medicine procedures performed in 2 nuclear medicine departments in golestan province were collected during 4 years. effective dose, collective effective dose and effective dose per examination were calculated u...

PURPOSE To investigate i.v. administration of delimotecan (MEN 4901/T-0128), a carboxymethyldextran polymer prodrug of the active camptothecin derivative T-2513, and to assess the maximum tolerated dose, safety profile, clinical pharmacology, and antitumor activity of delimotecan and metabolites. EXPERIMENTAL DESIGN Patients with solid tumors refractory to standard therapy received i.v. delim...

Introduction The Gamma Knife system is designed solely for non-invasive treatment of brain disorders, and it benefits from stereotactic surgical techniques. Dose calculations required in the system are performed by GammaPlan code; in this code, brain tissue is considered uniform. In the present study, we evaluated the effect of Gamma Knife system on the obtained dose through simulating a real ...

PURPOSE The dose-limiting toxicities, maximum tolerated dose, pharmacokinetic profile, and preliminary antitumor activity of neratinib (HKI-272), an irreversible pan ErbB inhibitor, were determined in patients with advanced solid tumors. EXPERIMENTAL DESIGN Neratinib was administered orally as a single dose, followed by a 1-week observation period, and then once daily continuously. Planned do...

background: in vivo dosimetry is a method for estimation of overall error in the delivered dose to the patients at the end of radiotherapy process. in this research, two methods for target dose calculation were evaluated on midline and central axis of photon beams in in vivo dosimetry of thorax fields. materials and methods: entrance and exit doses for anterior and lateral fields of thorax were...