Bacille Calmette-Guerin (BCG) vaccine is administered to all newborns in countries where tuberculosis is still endemic. It is a live attenuated vaccine and considered quite safe in immunocompetent children. Disseminated BCG disease is the most serious complication seen only in individuals with underlying primary or secondary immunodeficiencies. We report a case of disseminated BCG disease in an...

most people infected with m .tuberculosis do not develop active disease. in healthy individuals, the lifetime risk of developing infection to disease is 5-10%. reactivation of tb often occurs in older children and adolescent and is more common in patients who acquire tb at age 7 years and older. pulmonary tuberculosis may manifest in several forms, including endobronchial tb with focal lymphade...

PURPOSE There are considerable variations in the number of adverse reaction reports related to vaccine from different countries. The aim of this study was to review the development of adverse reactions to bacille Calmette-Guérin (BCG) vaccination among hospitalized patients in an Iranian referral hospital. MATERIALS AND METHODS We identified hospitalized patients with BCG complications in Ped...

Transitional-cell carcinoma of the bladder is an aggressive and potentially fatal malignancy. In 1990, the US Food and Drug Administration approved the use of intravesicular bacillus CalmetteGuérin (BCG) for the treatment of superficial bladder cancer.1 BCG is a live, attenuated strain of Mycobacterium bovis (M. bovis) that has been used to treat transitional-cell carcinoma since 1976 and has b...

INTRODUCTION Diagnosis of specific molecular defects of Mendelian susceptibility to mycobacterial diseases (MSMD) patients is important with respect to their clinical outcomes and their response to therapy. The aim of this study was to perform functional tests on blood samples of a group of patients who were suspected of having MSMD. METHODS This study was performed on 11 cases who had mycoba...

To the Editor: BCG (Mycobacte-rium bovis BCG) is a vaccine for preventing childhood tuberculosis (TB), especially military and meningeal TB. Because Taiwan has an annual TB incidence rate of ≈70 cases/100,000 persons, the National Immunization Program has included neonatal BCG vaccination since 1965. The coverage rate has remained at 97% since 2001. According to the Taiwan Tuberculosis Registry...

Complete IFN-γ receptor ligand-binding chain (IFNγR1) deficiency is a rare, life-threatening, autosomal recessive human immune deficiency (MIM107470) (1, 2). Affected children invariably develop disseminated bacille Calmette-Guérin (BCG) infection shortly after inoculation with live BCG vaccine (3–6). Rare survivors and nonvaccinated children develop severe infections caused by environmental no...