نتایج جستجو برای: disposition kinetics
تعداد نتایج: 108195 فیلتر نتایج به سال:
A mechanistic, multiscale mathematical model of immunogenicity for therapeutic proteins was formulated by recapitulating key biological mechanisms, including antigen presentation, activation, proliferation, and differentiation of immune cells, secretion of antidrug antibodies (ADA), as well as in vivo disposition of ADA and therapeutic proteins. This system-level model contains three scales: a ...
Butyrylcholinesterase administration has been shown to block the effects of cocaine. However, even in model systems, the pharmacokinetics of the enzyme are only partly understood. Measurements of plasma enzyme concentration, antibody titer determinations, and measurement of cocaine-induced locomotor activity in mice were used to describe the disposition of butyrylcholinesterase. Clearance of th...
Introduction: Today, the development of critical thinking skills and disposition in universities are one of the most important goals of higher education. The aim of this study was to determine the critical thinking disposition among postgraduate students of Medical faculty in Ahvaz Jundishapur University of Medical Sciences in Iran, 2017. Method: In a descriptive cross-sectional study, critica...
13-c/s-Retinoic acid (13-CRA) is a synthetic analog of vitamin A effective in reversing preneoplastic lesions in both humans and animals. To study its physicochemical properties and disposition kinetics, we developed a rapid, sensitive, and pre cise high-performance liquid chromatography assay for 13CRA in biological samples. This assay system resulted in a clear separation of 13-CRA from all-f...
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