Hypertension and chronic volume overload are complications often seen in hemodialysis patients. Current hemodialysis practices adopt a standard dialysate sodium prescription that is typically higher than the plasma sodium concentration of most patients. As a general rule, hemodialysis patients have stable predialysis plasma sodium concentrations, and each patient has a fixed "osmolar set point....

The goal of dialysis for patients with chronic renal failure is to restore the composition of the body’s fluid environment toward normal. This is accomplished principally by formulating a dialysate whose constituent concentrations are set to approximate normal values in the body. Over time, by diffusional transfer along favorable concentration gradients, the concentrations of solutes that were ...

INTRODUCTION Dialysis is an effective treatment for end-stage renal disease, but it is available to only approximately half of those who need it in the world. METHODS Two prototype passive-flow dialysate delivery systems were constructed. RESULTS Each dialysate delivery system provided a flow of dialysate in the range of 200-300 mL/minute. In one example, flow regulation was good, but ultra...

cluded that both dialysate calcium and plasma phosphate were important determinants of the parathyroid function in HD patients. During the last decade, several studies have demonstrated that this conclusion could be a subject for discussion. Recently, in a randomized clinical trial, Ok et al. [4] showed that lowering dialysate calcium levels slowed the progression of coronary artery calcificati...

The purpose of this study was to compare the metabolic properties of maintenance hemodialysis patients treated with glucose-containing and glucose-free dialysate using metabonomics. Pre- and post-dialysis serum samples from group G (-) using glucose-free dialysate, and group G (+) using glucose-added dialysate (glucose levels were 5.5 mmol/L) were analyzed and tested with high performance liqui...

Hyperchloremia is one of the multiple etiologies of metabolic acidosis in hemodialysis (HD) patients. The aim of the present study was to determine the influence of chloride dialysate on metabolic acidosis control in this population. We enrolled 30 patients in maintenance HD program with a standard base excess (SBE) ≤2 mEq/L and urine output of less than 100 mL/24 h. The patients underwent dial...

1. In eight patients being treated by chronic dialysis the relation of magnesium metabolism to the magnesium concentration of the dialysate was investigated. During four periods of 2-6 weeks the magnesium concentrations of the dialysis fluid were 0'44±0'15 mg/IOO ml, 0'70±0'24 mg/IOO ml, 1'83±0'18 mg/IOO ml and 1'97±0'21 mg/IOO ml. 2. During all periods the concentration of plasma magnesium and...

We conducted a prospective, randomized study to compare conventional continuous venovenous hemodiafiltration (CVVHDF) with sustained hemodiafiltration (SHDF) using an acetate-free dialysate. Fifty critically ill patients with acute kidney injury (AKI) who required renal replacement therapy were treated with either CVVHDF or SHDF. CVVDHF was performed using a conventional dialysate with an efflu...

Received 8/30/2000; accepted 9/18/2000. For Correspondence or reprints contact: Nan-Tsing Chiu, M.D., Department of Nuclear Medicine, National Cheng Kung University Hospital, 138, Shing-Li Road, Tainan 704, Taiwan. Tel:(886)6-2353535 ext. 2480 Fax: (886)6-2766609 E mail: [email protected] Background: Continuous ambulatory peritoneal dialysis (CAPD) has several advantages. However, some co...

BACKGROUND/AIMS We assessed changes in hemodynamic and arterial stiffness parameters following reductions of dialysate calcium concentrations in patients undergoing hemodialysis. METHODS In this prospective study, 20 patients on maintenance hemodialysis (10 females, 10 males) with dialysate calcium concentrations of 1.75 mmol/L were enrolled. At the start of the study, the dialysate calcium l...