Background Diabetic foot complications are recognised as the most common reason for diabetic related hospitalisation and lower extremity amputations. Multi-faceted strategies to reduce diabetic foot hospitalisation and amputation rates have been successful. However, most diabetic foot ulcers are managed in ambulatory settings where data availability is poor and studies limited. The project aime...

BACKGROUND Health-related quality of life (HRQoL) and health preference of patients with diabetes mellitus (DM) are essential in health economic evaluations but data on Chinese population is rare. This study aims to evaluate HRQoL and health preference of diabetic patients with different diabetic complications in Chinese population. METHODS A cross-sectional study was conducted in 1275 patien...

Diabetic ketoacidosis (DKA) is one of the most common fatal complications diabetes and often associated with severe underlying disease. The COVID-19 infection follows an intense course in patients comorbidities such as diabetes. Herein we presented a case diabetic caused by infection.

Diabetes is increasing at an alarming rate and, despite anti-hypertensive and insulin therapies, diabetic patients are still at risk of developing complications such as chronic kidney disease, cardiovascular disease, and retinopathy. There is therefore an urgent need for more effective therapies to prevent the development and progression of diabetic complications. Oxidative stress is a major pl...

OBJECTIVE To compare employment and income of working-age (18-64 years) people with and without diabetes. RESEARCH DESIGN AND METHODS We conducted a prospective population-based cohort study based in Manitoba, Canada, consisting of 25,554 individuals without diabetes and 608 with diabetes, of whom 242 had a complication of the disease. Adjusted odds ratios (ORs) of employment and income varia...

Diabetic nephropathy is a significant cause of chronic kidney disease and end-stage renal failure globally. Much research has been conducted in both basic science and clinical therapeutics, which has enhanced understanding of the pathophysiology of diabetic nephropathy and expanded the potential therapies available. This review will examine the current concepts of diabetic nephropathy managemen...

Diabetic Ketoacidosis (DKA) is one of the two important metabolic complications of diabetes, the other being hyperglycaemic hyperosmolar non-ketotic state (HHNS). DKA consists of the triad of hyperglycaemia, ketosis and acidosis; the diagnostic criteria being blood glucose level > 250 mg/dl, arterial pH < 7.3, bicarbonate level < 15 mEq/L and a moderate degree of ketonaemia and ketonuria. There...

The concept that excess superoxide production from mitochondria is the driving, initial cellular response underlying diabetes complications has been held for the past decade. However, results of antioxidant-based trials have been largely negative. In the present review, the data supporting mitochondrial superoxide as a driving force for diabetic kidney, nerve, heart, and retinal complications a...

Oxidative stress plays a pivotal role in the development of diabetes complications, both microvascular and cardiovascular. The metabolic abnormalities of diabetes cause mitochondrial superoxide overproduction in endothelial cells of both large and small vessels, as well as in the myocardium. This increased superoxide production causes the activation of 5 major pathways involved in the pathogene...