The review1 on ‘Progesterone receptor modulators in gynaecological practice’ in the April 2010 issue of the Journal is a valuable contribution to the available literature on a currently important subject. In the section on ‘Contraception’ the authors have dealt at length with mifepristone. Since the latter is not licensed for postcoital contraception, it would have been appreciated if the autho...

Controversial results obtained from human and animal studies on the prevention of heart disease by estrogens and progestins warrant a better understanding of nuclear hormone receptor function and interaction. To address this issue and taking into account that effects of synthetic progestins are not only referable to action through the progesterone receptor but may also be mediated by other ster...

OBJECTIVES Uterine fibroids are the most common benign tumors in women of reproductive age. Evidence suggest that ovarian steroid hormones, in particular, progesterone play a major role in promoting leiomyoma development and growth. For the last years there was an extensive research on selective progesterone receptor modulators and their use in therapy. Ulipristal acetate (UPA) is one of these ...

The objective of this study was to evaluate three methods of estrous synchronization, viz. controlled internal drug releasing device (CIDR), intravaginal sponges impregnated with fluogestone acetate (FGA), and cloprostenol (Estrumate; an analogue of prostaglandin F2α) in Nadooshani goats of Yazd province, Iran.The estrous synchronized does (n = 30 to 33 per treatment), after heat detection, wer...

-It has been shown that ovarian steroid hormones can reduce the incidence of cardiovascular disease in postmenopausal women. As hormone replacement therapy for postmenopausal women, progestins are added to estrogens to eliminate the increased risk of endometrial cancer. However, the effects of progestins on the atherogenic process have not been well understood. In the present study, we examined...

Introduction: Emergency contraception is the use of a birth control method after coitus has taken place and there fear that it may lead to pregnancy. Historical attempts were more likely be harmful rather than effective. Oral estrogens, progestins, anti-progesterone, partial agonist/antagonists progesterone have all been used with varying degrees efficacy. Currently ...

BACKGROUND Given after brain injury (TBI), progesterone reduces cerebral oedema and facilitates functional recovery. Progesterone analogues have been synthesized for use in many medical conditions and exhibit different chemical and biological properties. Medroxyprogesterone acetate (MPA) is widely used in clinical practice, but oestrogen/MPA combinations may increase the risk of stroke and card...

Although it is well known that progesterone alters uterine contractility and plays an important role in maintenance of pregnancy, the biochemical mechanisms by which progesterone alters uterine contractility in human gestation are less clear. In this investigation we sought to identify progesterone-induced adaptations in human myometrial smooth muscle cells that may alter Ca2+signaling in respo...

Although long-term clinical use of progestins is associated with an increased incidence of breast cancers, their role in established cancers is unclear. Estrogens are considered to be the main mitogens in the majority of breast cancers. Whether progesterone affects proliferation and/or differentiation is under debate. To assess the role of progesterone in established breast cancers, we used T47...

This experiment was conducted to determine the reproductive performance of Arabian ewes treated with short and long-term progesterone devices in addition to low doses of equine chorionic gonadotropin (eCG) during the anoestrus season. A total of 36 ewes were divided into three groups: in group I vaginal sponges (60 mg medroxy progesterone acetate; (MAP)) were applied and removed after 6 days; i...