background: the main cause of discontinuing the use of depomedroxy progesterone acetate (dmpa) is irregular bleeding. this study compared placebo with two kinds of combined oral contraceptive pills including low dose (ldocp) and high dose (hdocp) on control of abnormal uterine bleeding in dmpa users. methods: ninety dmpa users complaining of bleeding were studied in a triple blind randomized cl...

Background and Aim: Contraception in the postpartum period is a significant problem. When used correctly, injectable hormonal contraceptives are one of most reliable methods contraception currently available. The purpose present study was to assess effect DMPA as short term contraceptive immediate women. Patients Methods: This prospective observational conducted on 130 women Gynaecology Departm...

background it seems that depot-medroxyprogesterone acetate (dmpa) use can have an effect on a woman’s oral health, and cause periodontal changes in adult women. however, there is little research in this regard and consensus has not been reached in the literature. objectives this study aimed to investigate the association between dmpa injection and periodontal health in reproductive age women. m...

Generally, progestogens, i.e. progesterone in combination with oestradiol esters, are used primarily in the treatment of menstrual irregularities to maintain endangered pregnancies. Their derivatives are orally active medroxyprogesterone acetate including hydroxyprogesterone caproate, chlormadinone acetate, megestrol acetate. Naturally occurring glucocorticoids are often used in medicine such a...

Progesterone is essential for maintaining pregnancy, and several authors have suggested that low peripheral concentrations of progesterone may be responsible for high rates of embryonic loss. The primary organ involved in the catabolism of progesterone is the liver, and cytochrome P450 2C and 3A sub-families account for a large proportion of this catabolism. Elucidating a mechanism to decrease ...

OBJECTIVES Progestogens have been poorly studied concerning their roles in endothelial physiology. Prostanoids are vasoactive compounds, such as thromboxane A2, a potent vasoconstrictor, and prostacyclin, a vasodilator. We examined the effects of two progestogens used clinically, progesterone and medroxyprogesterone acetate, on thromboxane A2 production by cultured human umbilical vein endothel...

Norethindrone (17beta-hydroxy-19-nor-17alpha-pregn-4-en-20-yn-3-one) and norethindrone acetate (17beta-acetoxy-19-nor-17alpha-pregn-4-en-20-yn-3-one) interfered to a varying degree, by competitive inhibition, with the binding of progesterone and oestradiol to respective cytoplasmic receptors in the human uterus. Progesterone binding to 4S macromolecule was saturable and co-specific for progesti...