Objectives/Goals Human mast cells produce histidine decarboxylase, which catalyzes the histidine decarboxylation reaction, converting histidine to histamine. This reaction causes histamine to attach to receptors in the immune system, resulting in allergy symptoms. Current treatments for hay fever include antihistamines, a class of chemicals that prevent histamine from attaching to these recepto...

Iodobenzene diacetate was employed as a mild and efficient reagent for one-pot oxidative decarboxylation of tetrahydro-β-carboline acids and dehydrogenation of tetrahydro-β-carbolines to access the corresponding aromatic β-carbolines. To the best of our knowledge this is the first synthesis of β-carbolines via a one-pot oxidative decarboxylation at ambient temperature. The utility of this proto...

During an investigation of the decarboxylation of L-malate by cells of Lactobacillus arabinosus, 17-5 (Noesal, 1951 a) it was observed that pyruvate also yielded carbon dioxide. Like the decarboxylation ofmalate, the decompositioin ofpyruvate was found to be most rapid in the presence of glucose, potassium chloride and manganous chloride. Under most conditions the decomposition of pyruvate in L...

Malic dehydrogenase has been shown to catalyze the reduction of diketosuccinate by DPNH (4). Furthermore, both oxaloglycolate and diketosuccinate undergo spontaneous decarboxylation in aqueous solution. These nonenzymatic reactions complicate the analysis of the metabolic path of degradation of tartrate. As a prerequisite for the use of labeled compounds to study the biochemical synthesis and d...

Malic enzymes catalyze the oxidative decarboxylation of L-malate to pyruvate and CO(2) with the reduction of the NAD(P)(+) cofactor in the presence of divalent cations. We report the crystal structures at up to 2.1 A resolution of human mitochondrial NAD(P)(+)-dependent malic enzyme in different pentary complexes with the natural substrate malate or pyruvate, the dinucleotide cofactor NAD(+) or...

Evidence that indoleacetic acid (IAA) conjugates are metabolized via enzyme-catalyzed hydrolysis to free IAA and that their biological activities are related to the rates at which they are hydrolyzed by the tissue is presented. These conclusions are based on the following observations. Slow but continuous decarboxylation of the IAA moiety of IAA-l-alanine and IAA-glycine occurs when these conju...

The oxidative decarboxylation of levulinic acid (LA) by silver(I)/persulfate [Ag(I)/S₂O₈²⁻] has been investigated in this paper. The effects of buffer solution, initial pH value, time and temperature and dosages of Ag(I)/S₂O₈²⁻ on the decarboxylation of LA were examined in batch experiments and a reaction scheme was proposed on basis of the reaction process. The experimental results showed that...