It is essential to monitor the utilisation of antibacterial drugs in order to establish appropriate measures for their control. The pattern of usage of antibacterial drugs, and its association with indicators of hospital infection, has been investigated in a non-specialized adult intensive care unit (ICU) located in Santa Luzia Hospital (Brasília, DF, Brazil). The study was conducted between Ja...

Disc degenerative disease (DDD) is believed to originate in the nucleus pulposus (NP) region therefore, it is important to obtain a greater number of active NP cells for the study and therapy of DDD. Human induced pluripotent stem cells (iPSCs) are a powerful tool for modeling the development of DDD in humans, and have the potential to be applied in regenerative medicine. NP cells were isolated...

OBJECTIVES We aimed to compare the hemodynamic effects of right-atrial-paced (DDD) and right-atrialsensed (VDD) biventricular paced rhythm on cardiac resynchronization therapy (CRT). BACKGROUND Cardiac resynchronization therapy improves hemodynamics in patients with severe heart failure and left ventricular (LV) dyssynchrony. However, the impact of active right atrial pacing on resynchronizatio...

BACKGROUND Dense deposit disease (DDD) is an uncommon cause of end-stage renal disease (ESRD). As a consequence, information on the outcome of renal transplantation in patients with DDD comes from series with a limited number of patients. METHODS We present the histological and clinical data of 13 adult patients with DDD, who received their first allograft in our centre in the period between ...

The DDD-FM9001 is a 32-bit general purpose microprocessor formally derived directly from Hunt's mechanically veri ed Nqthm FM9001 microprocessor speci cation. The exercise was part of a project to construct an implementation of the FM9001 by applying the DDD design derivation system to the Nqthm FM9001 speci cation. The main thesis of this work maintains that derivation and veri cation represen...

Results Non-pacing associated (no pacing, no S-L-S) and pacing associated (ventricular pacing without S-L-S) onset accounted for 44.0% and 29.8% of all VT/VF, respectively. Pacing permitted (S-L-S sequences without ventricular pacing) episodes accounted for 6.4% (DDD/R), 20.0% (MVP), and 25.6% (VVI/R) of 1,356 VT/VF episodes. Pacing facilitated onset (S-L-S sequences actively facilitated by ven...

Complement component C3 glomerulopathy (C3GP) is a recently defined entity characterized by predominant glomerular C3 fragment deposition with absent or scanty immunoglobulin deposition due to abnormal control of complement activation, deposition, or degradation.[1] C3GP is subcategorized morphologically into dense deposit disease (DDD) and C3 glomerulonephritis (C3GN) based on electron microsc...

Materials science simulations are among the leading applications for scientific supercomputing. Discrete dislocation dynamics (DDD) is a numerical tool used to model the plastic behavior of crystalline materials using the elastic theory of dislocations. DDD simulations require very long running times to produce meaningful scientific results. This paper presents early experiences and results on ...

OBJECTIVES To evaluate the impact of an intervention to reduce the duration of antibiotic treatment for pneumonia in a neurosurgical intensive care unit (ICU). The usage of antibiotics and the resultant costs were examined using interrupted time series analysis while resistance and device-associated infection rates are also described. METHODS In January 2004, revised guidelines for the use of...