Adrenocorticosteroid activity in Lyon hypertensive (LH) and low blood pressure (LL) rat strains differ in several respects. Abnormal activity of 11beta-hydroxysteroid dehydrogenase enzymes (11beta-HSD1 and 11beta-HSD2), which interconvert corticosterone and inactive 11-dehydrocorticosterone, might contribute to the LH phenotype by regulating corticosteroid hormone access to receptors. 11beta-HS...

Adrenocorticosteroid activity in Lyon hypertensive (LH) and low blood pressure (LL) rat strains differ in several respects. Abnormal activity of 11b-hydroxysteroid dehydrogenase enzymes (11b-HSD1 and 11b-HSD2), which interconvert corticosterone and inactive 11-dehydrocorticosterone, might contribute to the LH phenotype by regulating corticosteroid hormone access to receptors. 11b-HSD2 (expresse...

The administration of cortisone to chick embryos inoculated with large quantities of inactive influenza B virus results in a rate of viral increase greater than is concommittantly observed with inocula of comparable infectivity which are devoid of inactive particles. Thus, more than a mere negation of autointerference is effected. It is concluded that in the presence of cortisone reactivation h...

We measured cortisol and cortisone in plasma--both total and free--and in saliva during the course of pregnancy and postpartum. Antepartum and postpartum concentrations and morning and afternoon concentrations of both steroids were compared. The mean concentrations of cortisol and cortisone increased towards term and were significantly greater at the end of pregnancy than postpartum, except for...

In mice receiving large amounts of cortisone for one week the total incidence of pericarditis, myocarditis, and of abscesses in kidneys, liver and myocardium was approximately 20 per cent. Simultaneous administration of cortisone and androgen increased the incidence of such lesions.' In these experiments myocardial necrosis occurred almost entirely in association with the inflammatory lesions m...

BACKGROUND Crohn's disease is a chronic inflammatory disease of the alimentary tract. Azathioprine is an effective agent in the management of chronic active Crohn's disease leading to long term remission of disease activity. Such treatment leads to limited efficacy or side effects in a small subset of patients. AIMS To compare efficacy and side effects of treatment with azathioprine plus cort...

The role of cortisone in viral carcinogenesis was investigated by inoculating murine sarcoma virus (Moloney) into normal BALB/c and C57BL/6 weanling mice and into mice of the same strains pretreated with 2.5 mg of cortisone acetate. The two strains were equally susceptible to tumor induction. Pre treatment with cortisone increased their susceptibility to oncogenesis. Fifty-four out of eighty no...