نتایج جستجو برای: core protein

تعداد نتایج: 1424777  

ژورنال: :پژوهش های آسیب شناسی زیستی 0
nasrin rastgoo m.sc. in medical biotechnology, tarbiat modares university, tehran, iran. ali karami ph.d. in biotechnology, associate professor, bagyatallah university, tehran, iran. farzaneh sabahi ph.d. in virology, associate professor, tarbiat modares university, tehran, iran

مقدمه: ویروس هپاتیت c یکی از مهمترین عوامل ایجادکننده هپاتیت حاد ومزمن، سیروز و سرطان کبد در سطح جهان محسوب می شود. به دلیل روند رو به رشد ابتلا به hcv در سطح دنیا تحقیقات گسترد ه ای در نقاط مختلف جهان برای افزایش کیفیت روشهای تشخیصی و تعیین ژنوتیپ ویروس در حال انجام است. روشها: در این تحقیق ناحیه ژنی مربوط به پروتئین نوکلئوکپسید ویروس (ژن core) که یک ناحیه بسیار حفاظت شده درطول ژنوم ویروس است،...

Journal: :The Kobe journal of medical sciences 2001
M Takamatsu T Fujita H Hotta

Hepatitis C virus (HCV) core protein either enhances or inhibits apoptosis depending on the apoptosis-inducing stimuli and cell conditions. In this paper we studied possible effect of HCV core protein on apoptosis induced by serum starvation. NIH3T3 cells stably expressing HCV core protein were more resistant to serum starvation-induced apoptosis than were the non-expressing control. Neither p5...

Journal: :Expert Opinion on Therapeutic Targets 2017

Journal: :The Journal of biological chemistry 2003
Niki Vassilaki Penelope Mavromara

HCV-1 produces a novel protein, known as ARFP, F, or core+1. This protein is encoded by an open reading frame (ORF) that overlaps the core gene in the +1 frame (core+1 ORF). In vitro this protein is produced by a ribosomal frameshift mechanism. However, similar studies failed to detect the ARFP/F/core+1 protein in the HCV-1a (H) isolate. To clarify this issue and to elucidate the functions of t...

Journal: :Journal of virology 2008
Kiyoko Okamoto Yoshio Mori Yasumasa Komoda Toru Okamoto Masayasu Okochi Masatoshi Takeda Tetsuro Suzuki Kohji Moriishi Yoshiharu Matsuura

Hepatitis C virus (HCV) core protein has shown to be localized in the detergent-resistant membrane (DRM), which is distinct from the classical raft fraction including caveolin, although the biological significance of the DRM localization of the core protein has not been determined. The HCV core protein is cleaved off from a precursor polyprotein at the lumen side of Ala(191) by signal peptidase...

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