To the Editor: pliance with therapy. Annual rates of vaso-occlusive crisis were calculated as previously described by dividing the number of crises by the number of years of therapy (for example, 2 crises Increased synthesis of fetal hemoglobin may ameliorate the cliniin 6 months Å 4 crises per year). The number of days spent in cal severity of sickle cell disease; both chemotherapeutic and non...

Valproic acid, a branched short-chain fatty acid, has numerous action mechanisms which turn it into a broad spectrum anticonvulsant drug and make its use possible in some other pathologies such as bipolar disorder. It is extensively metabolized in liver, representing β -oxidation in the mitochondria one of its main metabolic route (40%). Carnitine is responsible for its entry into the mitochond...

BACKGROUND A patient with an early diagnosed epilepsy Valproic acid is one of the most widely used antiepileptic drugs. Hyperammonemic encephalopathy is a rare, but potentially fatal, adverse drug reaction to valproic acid. CASE DESCRIPTION A patient with an early diagnosed epilepsy, treated with valproic acid, experienced an altered mental state after 10 days of treatment. Valproic acid seru...

objective(s) the role of therapeutic drug monitoring (tdm) in patient care has grown rapidly since its introduction three decades ago. the aim of present study was to evaluate the possible relationship between serum levels and the clinical response of valproic acid (vpa). materials and methods in the present study we evaluated a homogeneous group of adult patients receiving vpa monotherapy. a t...

BACKGROUND/AIM We have previously reported that caffeine can enhance chemotherapy efficacy of bone and soft-tissue sarcoma via cell-cycle perturbation. Valproic acid has histone deacetylase (HDAC) inhibitory activity. The present study aimed to investigate the efficacy of the combination of valproic acid and caffeine on human osteosarcoma cells in vitro and in orthotopic nude-mouse models. MA...

objective(s):the limited homing potential of bone-marrow-derived mesenchymal stem cells (bm-msc) is the key obstacle in msc-based therapy. it is believed that chemokines and chemokine receptor interactions play key roles in cellular processes associated with migration. meanwhile, mscs express a low level of distinct chemokine receptors and they even lose these receptors on their surface after a...

background epilepsy is a chronic neurological disease with the prevalence of around one percent. despite the introductions of several anti-epileptic drugs, around 1/3 of epileptic patients are resistant to the anti-epileptic medications. objectives considering the evidence regarding the anti-oxidant action of vitamin e and its beneficiary effect in the treatment of epilepsy, we investigated the...

The vaporization enthalpy of valproic acid (2-propylpentanoic acid) is reported, and the vapor pressures of a series on aliphatic carboxylic acids are used to evaluate its vapor pressure as a function of temperature. The vaporization enthalpy was derived by correlation-gas chromatography. This resulted in a vaporization enthalpy, ΔHvap(298.15 K) of (74.8 ± 2.4) kJ·mol−1. Vapor pressures from T/...

The studies of cell plasticity and differentiation abilities are important problems in modern cellular biology. The use of histone deacetylase inhibitor - valproic acid is a promising approach to increasing the differentiation efficiency of various cell types. In this paper we investigate the ability of mouse submandibular salivary gland cells to differentiate into the hepatic direction and the...