The authors investigate the effect of bumetan ide, an inhibitor of NKCC1 and a loop diuretic, on the tone of human umbilical artery (HUA). Rings of HUA (n = 35) from vaginal deliveries were suspended for isometric tension recordings in organ baths. Cumulative concentration-response curves to serotonin, histamine, and KCl were performed in the absence (control) or in the presence of bumetanide. ...

preterm contraction of uterus is a main cause of miscarriages and preterm labour. euphorbia known as ferphion in iranian traditional medicine texts like al-hawi, is reported for prevention of preterm labour. therefore, the objective of this research was to investigate the effect of euphorbia spinidens bornm. ex prokh. on motility of rat uterus. uterine horns were isolated form non-pregnant fema...

Dennettia tripetala (DT) is a tree found in rain forest belt of Nigeria, Cameroon and Ivory Coast. The seed commonly used preparing food for mothers after delivery because it believed to play role postpartum uterine contraction. There however no scientific evidence validating this claim. Hence, the study aimed investigate effects DT on non-pregnant pregnant uterus using mouse model. dried seeds...

Dessy, Chantal, Inkyeom Kim, Carrie L. Sougnez, Regent Laporte, and Kathleen G. Morgan. A role for MAP kinase in differentiated smooth muscle contraction evoked by a-adrenoceptor stimulation. Am. J. Physiol. 275 (Cell Physiol. 44): C1081–C1086, 1998.—The purpose of this study was to investigate the potential role of mitogen-activated protein (MAP) kinase in smooth muscle contraction by monitori...

introduction: dill (anethum graveolens), a herb from from umbelliferae, is used traditionally to treat convulsion and increasing milk production. its antimicrobial, antihyperlipidaemic, anti-hypercholesteroaemic effects and gastric acid secretion reducing effect have been reported. the spasmolytic effect of dill fruit on rat uterus has also been shown recently. the aim of present study was to i...

The effects of extracellular rubidium chloride (1, 2, 4, and 8 HIM) on simultaneously recorded transmembrane action potentials and contractions of human papillary muscle in potassium-free solutions were investigated. In KCl-free solution, reduction in the duration of the action potential at the 25% and 50% levels of repolarization was associated with an increase in the force of contraction. Exp...

In previous studies, we have shown the relaxatory effect of grape leaf (Vitis vinifera) extract on isolated ileum, uterus and aorta. In rat aorta it was revealed that the NO and endothelium are involved in the relaxation induced by grape leaf extract. The aim of present study was to investigate the effect of the Vitis vinifera leaf hydroalcoholic extract (VLHE) on rat trachea precontracted by A...

Nitric oxide (NO) relaxes most smooth muscle, including the circular smooth muscle (CSM) of the esophagus, whereas in the adjacent longitudinal smooth muscle (LSM), it causes contraction. The second messenger pathways responsible for this NO-induced LSM contraction are unclear, given that these opposing effects of NO are both cGMP dependent. In intestinal LSM, but not CSM, cADP ribose (cADPR)-d...

In previous studies, we have shown the relaxatory effect of grape leaf (Vitis vinifera) extract on isolated ileum, uterus and aorta. In rat aorta it was revealed that the NO and endothelium are involved in the relaxation induced by grape leaf extract. The aim of present study was to investigate the effect of the Vitis vinifera leaf hydroalcoholic extract (VLHE) on rat trachea precontracted by A...

Drotaverine is considered an inhibitor of cyclic-3',5'-nucleotide-phophodiesterase (PDE) enzymes; however, published receptor binding data also support the potential L-type voltage- operated calcium channel (L-VOCC) blocking effect of drotaverine. Hence, in this work, we focus on the potential L-VOCC blocking effect of drotaverine by using L-VOCC-associated functional in vitro models. According...