we investigated contraction to noradrenaline (na) and kc1 and sensitivity of na at the level of larger vessels (thoracic aorta and vena cava; left renal artery and left renal vein; lateral saphenous artery and lateral saphenous vein and finally central ear artery and marginal ear vein) in a model devised to mimic heart failure. the model presented here is the rabbit coronary ligation model in w...

prangos ferulacea is a plant found in the mediterranean and middle-east regions used as carminative, anti-flatulent, emollient and antibacterial herb. it is believed that the coumarins are responsible for some of known effects of  prangos . in this research the relaxant effects of p. ferulacea coumrin rich extract as well as osthole as its main prenylated coumarins were investigated on rat ileu...

zataria multiflora boiss. is used in iranian traditional medicine to treat gastrointestinal disorders and menrrhalgia. the inhibitory effect of this herb on rat ileum contractions is also reported. the aim of this study was to investigate the effect of zataria multiflora boiss. hydroalcoholic leaf extract (zhle) on isolated rat uterus in presence of some known uterus stimulants. pieces of virgi...

background: punica granatum linn. (pg) is native to the mediterranean region. its flower exhibited antioxidant activity. the present study attempt to investigate the effect of these extract on uterine contraction and its possible mechanism(s). methods: thirty five female wistar rats (200-300 g) at estrous phases of cycle was examined in this study; pieces of virgin adult rat uterus (1.5 cm) wer...

hydroalcoholic extract of pycnocycla spinosa is a relaxant of rat ileum and inhibits diarrhea in mice. as p. spinosa extract has spasmolytic activity on ileum, it could also affect other smooth muscles like bladder. therefore, the aim of this study was to determine the effect of p. spinosa extract on rat bladder contraction. in an in vitro study, the effects of p. spinosa extract, nifedipine an...

seeds of moringa peregrina (forssk.) fiori. (moringaceae) is widely used in south east of iran for gastrointestinal disorders. however, so far there is no pharmacological evidence for antispasmodic activity of this plant extract. therefore, the aim of this research was to investigate antispasmodic activity of m. peregrina on rat isolated ileum contraction. hydroalcoholic extract was obtained by...

Hydroalcoholic extract of Pycnocycla spinosa is a relaxant of rat ileum and inhibits diarrhea in mice. As P. spinosa extract has spasmolytic activity on ileum, it could also affect other smooth muscles like bladder. Therefore, the aim of this study was to determine the effect of P. spinosa extract on rat bladder contraction. In an in vitro study, the effects of P. spinosa extract, nifedipine ...

Hydroalcoholic extract of Pycnocycla spinosa is a relaxant of rat ileum and inhibits diarrhea in mice. As P. spinosa extract has spasmolytic activity on ileum, it could also affect other smooth muscles like bladder. Therefore, the aim of this study was to determine the effect of P. spinosa extract on rat bladder contraction. In an in vitro study, the effects of P. spinosa extract, nifedipine ...

Airway smooth muscle (ASM) membrane depolarization through KCl opens L-type voltage dependent Ca2+ channels (Ca(v)1.2); its opening was considered the cause of KCl contraction. This substance is used to bypass intracellular second messenger pathways. It is now clear that KCl also activates RhoA/Rho kinase (ROCK) pathway. ROCK isoforms are characterized as ROCK1 and ROCK2. Because ROCK1 seems th...

abstract   extract prepared from aerial part of pycnocycla spinosa is a relaxant of rat ileum contractions. the objective of this research was to study the spasmolytic activity of p. spinosa root extract for comparison with the aerial part extract. hydroalcoholic extracts were prepared by percolation method. a portion of rat ileum was removed and suspended under 1 g tension in tyrode’s solution...