نتایج جستجو برای: connexin43

تعداد نتایج: 1453  

Journal: :Circulation Research 2004

Journal: :Journal of Biological Chemistry 2004

Journal: :iranian biomedical journal 0
محمد سیاح mohammad sayyah بهار کاویانی bahar kaviani بهارک خوش خلق سیما baharak khoshkholgh-sima مرضیه باقری marzieh bagheri مریم اولاد maryam olad سمیرا چوپانی samira choopani رضا مهدیان

background: hippocampal damages, which are accompanied by inflammation, are among the main causes of epilepsy acquisition. we previously reported that chronic intracerebroventricular (i.c.v.) injection of lipopolysaccharide (lps) modulates epileptogenesis in rats. there is a network of gap junction channels in the hippocampus that contribute to epileptogenesis. gap junction channels are formed ...

Journal: :Stroke 2003
Hiroshi Ujiie Andrew T Chaytor Linda M Bakker Tudor M Griffith

BACKGROUND AND PURPOSE Direct intercellular communication via gap junctions may play a central role in endothelium-dependent relaxations that are mediated by a conducted hyperpolarization and do not involve the synthesis of NO and prostanoids. In the present study, inhibitory peptides homologous to the Gap27 domain of the second extracellular loop of connexin37/connexin43 and connexin40, design...

Journal: :International journal of clinical and experimental pathology 2015
Xin-Yun Ye Qiu-Hua Jiang Tao Hong Zhen-Yu Zhang Rui-Jin Yang Jin-Qing Huang Kun Hu Yu-Ping Peng

In this study, we aim to evaluate the connexin (Cx43) and phosphorylation Cx43 (p-Cx43) expression of human glioma tumors and correlate their expression with degrees of malignancy and proliferation, apoptosis, and migration activity of tumors. Cx43 and p-Cx43 expression were examined by Western blot analysis and immunohistochemical staining. The U251 cell viability was measured by MTT analysis....

2018
Sara Crespo Yanguas Tereza C da Silva Isabel V A Pereira Joost Willebrords Michaël Maes Marina Sayuri Nogueira Inar Alves de Castro Isabelle Leclercq Guilherme R Romualdo Luís F Barbisan Luc Leybaert Bruno Cogliati Mathieu Vinken

Although a plethora of signaling pathways are known to drive the activation of hepatic stellate cells in liver fibrosis, the involvement of connexin-based communication in this process remains elusive. Connexin43 expression is enhanced in activated hepatic stellate cells and constitutes the molecular building stone of hemichannels and gap junctions. While gap junctions support intercellular com...

2012
David W. Van Norstrand Jeffrey E. Saffitz Heather S. Duffy

Background—An estimated 10% to 15% of sudden infant death syndrome (SIDS) cases may stem from channelopathymediated lethal arrhythmias. Loss of the GJA1-encoded gap junction channel protein connexin43 is known to underlie formation of lethal arrhythmias. GJA1 mutations have been associated with cardiac diseases, including atrial fibrillation. Therefore, GJA1 is a plausible candidate gene for pr...

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