Abstract Tumor progression and therapeutic resistance in cancer have been strongly associated with stemness. Rather than focus on a discrete subpopulation for stemness tumor maintenance, we might explore as continuous variable through machine learning algorithms. We chose One Class Logistic Regression algorithm to define an epigenetic signature assess brain tumors using induced Neural Stem Cell...

Abstract Spinal cord injury (SCI) is a devastating condition with 250,000 to 500,000 new cases globally each year. Respiratory infections, e.g., pneumonia and influenza, are the leading cause of death after SCI. For instance, an individual SCI 37 times more likely become infected hospitalized from flu. Yet, field has poor understanding how immune dysfunction arises trauma central nervous system...

AIM To determine the activity of pseudocholinesterase (PChE) in cerebrospinal fluid (CSF) and serum in children with solid central nervous system (CNS) tumor and to assess whether PChE activity could be a valid biomarker for solid CNS tumors in children. METHODS The study and control group included 30 children each. Children in the study group had a solid CNS tumor, while those from the contr...

While the presence of metastatic melanocytoma in central nervous system (CNS) is relatively common, primary spinal (PSM) an extremely rare entity. Only 70 cases have been reported, and its usual position cervical region. We report a case 35-year-old male with intramedullary dorsal exophytic component. The tumor was first opened periphery closed without being operated upon due to it uncommon pat...

A granular cell tumor (GCT) in the central nervous system (CNS) of a ferret is rare finding. In this case cerebral GCT described 5-year-old castrated female ferret. The animal developed lameness right hind leg which progreseed to total ataxia. died and necropsy revealed mass medial caudal part left frontal lobe brain. Based on histological imunohistochemical findings, was diagnosed as tumor. Im...

Background: Reduced survival and impaired quality of life of the children affected by cancers is one of the most important health problems. In this study, 5-year survival of children affected with Central nervous system (CNS) tumors and its related factors were evaluated. Materials and Methods: Participants in this historical cohort study consisted of 161children with mean age of diagnosis 72 ...

The purpose of this study was to determine the role of neuroimaging in the management of patients with metastatic germ cell tumors. Retrospective evaluation of 299 patients treated in 1986 and 1987 for initial presentation or recurrence of testicular, retroperitoneal, and mediastinal germ cell tumors was performed to determine indications for neuroimaging, frequency and site of CNS metastases, ...

tumors of the central nervous system (cns), occur relatively frequently during the early years of life. they are the most common solid tumors of childhood and are second only to leukemia in overall cancer incidence and account for a high proportion of deaths. in different studied performed in several countries, astrocytomas and other gilomas (combined) account for half of the cns malignancies, ...

PURPOSE This review assesses the current state of knowledge regarding preclinical and clinical pharmacology for brain tumor chemotherapy and evaluates relevant brain tumor pharmacology studies before October 2006. RESULTS Chemotherapeutic regimens in brain tumor therapy have often emerged from empirical clinical studies with retrospective pharmacologic explanations, rather than prospective tr...

Abstract INTRODUCTION: Histologically diagnosed embryonal tumors (ET) of the central nervous system (CNS) in pediatric population represent a group aggressive malignancies with historically poor prognoses. Immunohistochemistry (IHC) and cytogenetics refined tumor classification improved treatment strategies. Modern advancements molecular methods including methylation profiling provide further d...