BACKGROUND AND OBJECTIVES Vaginal candidiasis is a common disease in women during their lifetime and occurs in diabetes patients, during pregnancy and oral contraceptives users. Although several antifungals are routinely used for treatment; however, vaginal candidiasis is a challenge for patients and gynecologists. The aim of the present study was to evaluate terbinafine (Lamisil) on Candida va...

Pathologic water loss from sickle erythrocytes concentrates the abnormal hemoglobin and promotes sickling. The Ca2+-activated K+ channel (Gardos channel) contributes to this deleterious dehydration in vitro, and blockade of K+ and water loss via this channel could be a potential therapy in vivo. We treated five subjects who have sickle cell anemia with oral clotrimazole, a specific Gardos chann...

The incidence of fungal infections has increased at an alarming rate in the past two decades. Topical Ketoconazole and Clotrimazole solutions are used to stop growth of fungus like Dermatophytes, Candidiasis and Pityrosporum. The objective of this study is to assess the effectiveness of prophylactic Ketoconazole or Clotrimazole solution wash in patients with fungal infections. Hundred patients ...

To determine the effect of Zataria multiflora vaginal cream in signs & symptoms of Candida vaginits. A randomized, double-blind clinical trial was performed comparing one applicator of Zataria multiflora vaginal cream with one applicator of Clotrimazole vaginal cream at night for a week. 61 women with candida vaginitis were enrolled. 30 of 62 women treated with Zataria multiflora vaginal cream ...

The lack of variation in antifungal drugs, and the misuse or inappropriate use usually causes resistant strains of the yeast in human’s normal flora. Unfortunately, a large number of Candida infection cases in immunosuppressed patients with insufficient treatment eventually can cause patient's death. The aim of this study was to evaluate the in vitro conventional antifungal azole compounds with...

background and purpose: candida species are the most opportunistic fungi affecting the nails and resulting in onychomycosis. in this study, we identified and evaluated in-vitro susceptibility of the recovered isolates against fluconazole (flc), voriconazole (vrc), and clotrimazole (clt) using the clinical and laboratory standards institute (clsi) m27-a3 document. materials and methods: from pat...

Clotrimazole and triadimefon are known as potent inhibitors of ergosterol synthesis in pathogenic yeast and fungi, respectively. As their mode of action generally the inhibition of sterol desmethylation reactions is accepted. We report about a second effect, a "feed-back" inhibition of 3-hydroxy-3-methyl-glutaryl (HMG)-CoA-reductase by accumulation of ergosterol precursors. Addition of lanoster...

the lack of variation in antifungal drugs, and the misuse or inappropriate use usually causes resistant strains of the yeast in human’s normal flora. unfortunately, a large number of candida infection cases in immunosuppressed patients with insufficient treatment eventually can cause patient's death. the aim of this study was to evaluate the in vitro conventional antifungal azole compounds with...