نتایج جستجو برای: cholinergic receptor
تعداد نتایج: 601300 فیلتر نتایج به سال:
Parkman, Henry P., Anthony P. Pagano, and James P. Ryan. Subtypes of muscarinic receptors regulating gallbladder cholinergic contractions. Am. J. Physiol. 276 (Gastrointest. Liver Physiol. 39): G1243–G1250, 1999.—The aim of this study was to determine the functional role of muscarinic receptor subtypes regulating gallbladder cholinergic contractions. Electrical field stimulation (EFS; 16 Hz) pr...
Schizophrenia is a severe, chronic mental disorder. The etiology remains unknown but alterations in cholinergic neurotransmission is one, among other, disturbances in the brain that have been implicated in schizophrenia. The main aim of the thesis projects has been to evaluate if disturbances in central cholinergic function can contribute to schizophrenic symptoms. In all studies an immunotoxin...
Emerging evidence suggests that the p75 neurotrophin receptor (p75NTR) mediates cell death; however, it is not known whether p75NTR negatively regulates other neuronal phenotypes. We found that mice null for p75NTR displayed highly significant increases in the size of basal forebrain cholinergic neurons, including those that are TrkA-positive. Cholinergic hippocampal target innervation also was...
The muscarinic acetylcholine receptor subtype 1 (M1) receptors play an important role in cognition and memory, and are considered to be attractive targets for the development of novel medications to treat cognitive impairments seen in schizophrenia and Alzheimer's disease. Indeed, the M1 agonist xanomeline has been shown to produce beneficial cognitive effects in both Alzheimer's disease and sc...
Background: Nowadays cardiac problems are the main cause of death. It includes coronary artery disease, angina pectoris (stable and unstable), congestive heart failure, etc. Objectives: The aim this paper was to generate scientific data regarding In silico analysis beta-sitosterol, coumaric acid, lupeol, qurecetin, urosolic acid Muscarinic (M2) receptor. Materials Methods: leaf powder treated w...
Our aim was to determine how the cholinergic environment influences, in vivo, the membrane abundance and the intracellular trafficking of the muscarinic receptor m4 (m4R). Immunohistochemistry at light and electron microscopic level was used to detect the subcellular localization of m4R in several populations of striatal cholinoceptive neurons, including cholinergic neurons and medium spiny neu...
Striatal cholinergic interneurons (ChIs) are central for the processing and reinforcement of reward-related behaviors that are negatively affected in states of altered dopamine transmission, such as in Parkinson's disease or drug addiction. Nevertheless, the development of therapeutic interventions directed at ChIs has been hampered by our limited knowledge of the diverse anatomical and functio...
Cholinergic input to the optic tectum is necessary for visual map maintenance. To understand why, we examined the effects of activation of the different cholinergic receptor subtypes in tectal brain slices and determined whether the retinotectal map was affected by manipulations of their activity in vivo. Both alpha-bungarotoxin sensitive and insensitive nicotinic receptor agonists increased sp...
Progressive supranuclear palsy (PSP) is a progressive neurodegenerative disease characterized by akinetic-rigid features, falls, a supranuclear gaze palsy and subcortical dementia. Pathologically, there is abnormal accumulation of tau protein. Cholinergic deficits are thought to underlie the postural instability and cognitive impairment of PSP, but trials of cholinergic agonists and cholinester...
The cholinergic hypothesis of Alzheimer’s disease has spurred the development of numerous compounds aimed at increasing central cholinergic neurotransmission. Symptomatic treatment can be given by cholinomimetics with the pharmacological profile of muscarinic receptor 1 (M1 receptor) agonist and/or acetylcholineesterase (AChE) inhibitors. Novel bioactive six-membered N-arylureasubstituted 3-mor...
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