BACKGROUND The clinical trials using immunotherapy have been performed for the treatment of variety of malignant tumors. However, large-scale meta-analysis of combined DC-CTL/CIK therapy on immune and clinical response in patients has not been well studied yet. The purpose of this study is to investigate the role of DC-CTL/CIK therapy and evaluate the changes of immune indicators and tumor sero...

Soluble mannose receptor (sMR) and soluble haemoglobin scavenger receptor (sCD163) are macrophage activation markers which have previously been demonstrated to be increased in patients with inflammation, auto-immunity and malignancies. To investigate the clinical diagnostic and prognostic significance of preoperative serum sMR and sCD163, the present study investigated 143 gastric cancer (GC) p...

Although microRNA‑33 (miR‑33) family members are known to be involved in the regulation and balancing of cholesterol metabolism, fatty acid oxidation and insulin signaling, their functions in carcinogenesis are controversial and the underlying mechanisms have remained elusive. Gastric cancer is the fourth most common malignancy in the world; however, the dysregulation and function of miR‑33 fam...

BACKGROUND Colorectal cancer (CRC) is one of the leading causes of cancer-related death all over the world. Ribosomal s6 kinase4 (RSK4), an X-linked gene, firstly was found as to be a potential tumor suppressive gene in a variety of cancers and is widely participated in signaling pathway. However its role in CRC is unclear. This study is to explore the correlation between the protein expression...

BACKGROUND This work was to evaluate the perioperative safety and efficacy of cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) with lobaplatin and docetaxel in patients with peritoneal carcinomatosis (PC) from gastrointestinal and gynecological cancers. METHODS Patients were treated by CRS + HIPEC with lobaplatin 50 mg/m(2) and docetaxel 60 mg/m(2) in 6000 mL...

Small bowel tumors are rare tumors. Duodenal tumors occur more commonly compared with other small intestinal tumors. To summarize the clinicopathological features of duodenal tumors, in the present study 44 cases of duodenal tumors were collected, and the comparative clinicopathological characteristics between tumors of the ampulla and non-ampulla, the choice of treatment, and differences in th...

AIM The purpose of this study is to develop a proteomic pattern for distinguishing individuals with colorectal cancer from healthy controls and monitoring micrometastasis using SELDI-TOF-MS. METHODS A training set consisting of 63 patients with colorectal cancer, 20 patients with benign colorectal diseases and 26 healthy volunteers was used to develop a proteomic model that discriminated colo...

A 60-year-old man, with occasional acid reflux, was found on computed tomography (CT) to have multiple masses in his esophagus (●" Fig.1a), stomach (●" Fig.1 d), and liver. He had a history of partial hepatectomy for inflammatory liver pseudotumor on two occasions, 22 and 9 years earlier. Physical examination revealed no superficial lymph node. Blood test showed that hemoglobin was 105g/L, and ...

ried out in a local hospital revealed expansion both within and outside the liver bile duct but found no stone or neoplasm. Then, she was referred to our hospital where physical examination revealed epigastric tenderness while the liver, spleen, and superficial lymph nodes were not palpable. The patient’s main laboratory data showed no abnormality except for a slight elevation of tumor markers ...

M gravis (MG) is an antibody-mediated autoimmune disorder affecting neuromuscular junctions, which is strongly associated with thymoma. Usually, the target of the autoimmune attack is the acetylcholine receptor (AChR) of the postsynaptic skeletal muscle endplate. However, non-AChR components, such as muscle-specific receptor tyrosine kinase (MuSK) and low-density lipoprotein receptor related pr...