We evaluated the hypothesis that nutritive needs of injured brains are supported by large and coordinated increases in lactate shuttling throughout the body. To that end, we used dual isotope tracer ([6,6-(2)H2]glucose, i.e., D2-glucose, and [3-(13)C]lactate) techniques involving central venous tracer infusion along with cerebral (arterial [art] and jugular bulb [JB]) blood sampling. Patients w...

BACKGROUND The rate of extra-hepatic lactate production and the route of influx of lactate to the liver may influence both hepatic and extra-hepatic lactate exchange. We assessed the dose-response of hepatic and extra-hepatic lactate exchange during portal and central venous lactate infusion. METHODS Eighteen pigs randomly received either portal (n=5) or central venous (n=7) lactate infusion ...

1. Twenty-three peritoneal dialyses with fluid containing 45 mEq lactate per litre were carried out on six patients with acute or chronic renal failure. During dialysis arterial blood pH and base excess rose. 2. The lactate ions were rapidly and almost completely absorbed from the fluid in the peritoneal cavity. Blood lactate concentration rose, but in patients with adequate liver function it d...

OBJECTIVES Although carbon monoxide poisoning is a major medical emergency, the armamentarium of recognized prognostic biomarkers displays unsatisfactory diagnostic performance for predicting cumulative endpoints. METHODS We performed a retrospective and observational study to identify all patients admitted for carbon monoxide poisoning during a 2-year period. Complete demographical and clini...

SPITZER,JOHN J.,A.A. BECHTEL, L.T. ARCHER, M.R. BLACK, AND L. B. HINSHAW. Myocardial substrate utiliZation in dogs following endotoxin administration. Am. J. Physiol. 227(l) : 132-136. 1974.Changes of myocardial substrate utilization have been studied in dogs under pentobarbital anesthesia following the administration of E. coli endotoxin. Myocardial substrate utilization under control conditio...

1. The effects of treadmill exercise on oxygen consumption (V02), carbon dioxide production (VCO2), arterial blood lactate concentration ([L-]a), arterial blood pH and arterial gas tensions (PaO2 and PaCO2) were measured in 3 species of lizards (Varanus salvator, V. exanthematicus, Iguana iguana) 2. Varanus salvator was exercised 45 min at an intensity which required 85% of its VO2 max. V. salv...

introduction: one of the main complications of hemodialysis in patients with chronic renal failure is hypoxemia which is related to several factors including the type of filter. the aim of this study was to evaluate the hypoxemia levels in patients undergoing hemodialysis with focus on the type of filter. methods: in a crossover clinical trial, 29 patients from emodialysis ward of fatemieh hosp...

background pulse-oximetry (spo2) widely uses as a help tools for therapeutic interventions in the pediatric intensive care units (picu). the aim of this study was to evaluate the validity of spo2 in measuring of oxygenation index (oi) in children. materials and methods in a descriptive analytical study, 100 patients who were admitted to picu tabriz children's hospital were studied. oxygena...

BACKGROUND Use of ephedrine in obstetric patients is associated with depression of fetal acid-base status. The authors hypothesized that the mechanism underlying this is transfer of ephedrine across the placenta and stimulation of metabolism in the fetus. METHODS A total of 104 women having elective Cesarean delivery under spinal anesthesia randomly received infusion of phenylephrine (100 mic...